{"metadata":{"accession":"A0A2U4C9C9","id":"A0A2U4C9C9_TURTR","source_organism":{"taxId":"9739","scientificName":"Tursiops truncatus","fullName":"Tursiops truncatus (Atlantic bottle-nosed dolphin)"},"name":"Polypyrimidine tract-binding protein 3","description":["Plays a role in pre-mRNA splicing and in the regulation of alternative splicing events. Activates exon skipping of its own pre-mRNA during muscle cell differentiation. Binds to the polypyrimidine tract of introns. May promote RNA looping when bound to two separate polypyrimidine tracts in the same pre-mRNA. May promote the binding of U2 snRNP to pre-mRNA. Cooperates with RAVER1 to modulate switching between mutually exclusive exons during maturation of the TPM1 pre-mRNA. Represses the splicing of MAPT/Tau exon 10. Binds to polypyrimidine-rich controlling element (PCE) of CFTR and promotes exon skipping of CFTR exon 9, thereby antagonizing TIA1 and its role in exon inclusion of CFTR exon 9. Plays a role in the splicing of pyruvate kinase PKM by binding repressively to a polypyrimidine tract flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform","RNA-binding protein that mediates pre-mRNA alternative splicing regulation. Plays a role in the regulation of cell proliferation, differentiation and migration. Positive regulator of EPO-dependent erythropoiesis. Participates in cell differentiation regulation by repressing tissue-specific exons. Promotes Fas exon 6 skipping. Binds RNA, preferentially to both poly(G) and poly(U)"],"length":552,"sequence":"MDGVVTDLIAVGLKRGSDELLSSDIVNGPFTMNSSTRSAANGNDNKKFKGDRPPCSPSRVLHLRKIPSDVTEAEVISLGLPFGKVTNLLMLKGKSQAFLEMASEEAAVTMVNYYTPVTPHLRSQPVFIQYSNHRELKTDNLPNQARAQAALQAVSAVQSGSLALPGAPANEGTILPGQSPVLRIIIENLFYPVTLEVLHQIFSKFGTVLKIITFTKNNQFQALLQYADPLNAHYAKMALDGQNIYNACCTLRIDFSKLTSLNVKYNNDKSRDFTRLDLPTGDGQPSLEPPMAFGAPGIISSPYAGAAGFAPAIGFPQATGLSVPAGLGPGALGPLAITSSAVTGRMAIPGAGGIPGNSVLLVTNLNPDLITPHGLFILFGVYGDVHRVKIMFNKKENALVQMADANQAQLAMNHLSGQRLYGKVLRATLSKHQAVQLPREGQEDQGLTKDFSNSPLHRFKKPGSKNFQNIFPPSATLHLSNIPPSVTVDDLKNLFTDAGCSVKAFKFFQKDRKMALIQLGSVEEAIQALIELHNHDLGENHHLRVSFSKSTI","proteome":"UP000245320","gene":"PTBP3","go_terms":[{"identifier":"GO:0003676","name":"nucleic acid binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0003723","name":"RNA binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006397","name":"mRNA processing","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0005634","name":"nucleus","category":{"code":"C","name":"cellular_component"}}],"protein_evidence":4,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"41e57ad083d6a04f9c691de8c8f2fc512151e2c2","counters":{"domain_architectures":5202,"entries":18,"isoforms":0,"proteomes":1,"sets":2,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":1,"ssf":1,"cdd":2,"profile":1,"smart":1,"pfam":3,"panther":1,"ncbifam":1,"interpro":7},"proteome":1,"taxonomy":1,"similar_proteins":5202}}}