{"metadata":{"accession":"A0A2U3XFB5","id":"A0A2U3XFB5_LEPWE","source_organism":{"taxId":"9713","scientificName":"Leptonychotes weddellii","fullName":"Leptonychotes weddellii (Weddell seal)"},"name":"Epithelial splicing regulatory protein 2","description":["mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT). Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2"],"length":717,"sequence":"MTPPPPQPPPPGPNPISDSAADPRLGPGPLVVLFGATAGALGPDLGSDETDLILLVWQVVEPRSRQVGTLHKSLVRAEAAALSPQCREASGLSADSLARAEPLDKVLQQFSQLVSGDVALLGGGPYMLCTDGQQLLRQVLHPEASRKNLVLPDTFFSFYDLRREFHVQHPSACPARELTVATMAQDLGLETDATEDDFGVWEVKTMVAVILHLLEGPSGQLFSKAEVVKQKYETGPCSKADAVDSETVVRARGLPWQSSDQDVARFFKGLNIARGGVALCLNAQGRRNGEALIRFVDSEQRDLALQRHKHHMGVRYIEVYKATGEEFVKIAGGTSLEVARFLSREDQVILRLRGLPFSAGPADVLGFLGPECPVTGGADGLLFVRHPDGRPTGDAFALFACEDLAQAALRRHKGMLGKRYIELFRSTAAEVQQVLNRYASSPLLPALAAPLLPIPFPLATGTGRDCVRLRGLPYTATIEDILSFLGEAAADIRPHGVHMVLNQQGRPSGDAFIQMTSAERALAAAQRCHKKVMKERYVEVVPCSTEEMSRVLMGGTLGRSGMSPPPCKLPCLSPPTYATFQATPALIPAETAALYPSSALLPAARVPAAPTPVAYYPGPAAQLYMNYTAYYPSPPVSPTTVGYLTTPPAALASASTSVLSQPGALVRMQGVPYTAGMKDLLSVFQAYQLAPDDYTSLMPVGDPPRTVLQAPKEWVCL","proteome":"UP000245341","gene":"ESRP2","go_terms":[{"identifier":"GO:0003676","name":"nucleic acid binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0003723","name":"RNA binding","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"bdf827d8b90aca965ea063a4255bf4b88713344d","counters":{"domain_architectures":5755,"entries":15,"isoforms":0,"proteomes":1,"sets":2,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":2,"ssf":2,"smart":1,"cdd":2,"pfam":1,"panther":1,"interpro":6},"proteome":1,"taxonomy":1,"similar_proteins":5755}}}