{"metadata":{"accession":"A0A2T4YV55","id":"A0A2T4YV55_9SPHN","source_organism":{"taxId":"185951","scientificName":"Sphingomonas aerolata","fullName":"Sphingomonas aerolata"},"name":"Serine hydroxymethyltransferase","description":["Catalyzes the reversible interconversion of alpha-methyl-L-serine to D-alanine with tetrahydrofolate (THF) serving as the one-carbon carrier. Cannot use alpha-methyl-D-serine, L-serine, D-serine or L-alanine","Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism"],"length":436,"sequence":"MSTQPNTLHDVQPDGFFTRGLADADAAVFAGVEAELEREQTQIELIASENIVSKAVLEAQGSVFTNKYAEGYPGKRYYQGCAPSDTVETLAIERAKQIFGCGFVNVQPHSGAQANGAVMLALVKPGDTILGMSLDAGGHLTHGAKPAQSGKWFNAIQYGVDATTHLIDYDQVEALAVEHQPKLIIAGGSAYPRVIDFARFRAIADKVGAYFMVDMAHFAGIVAAGLHPTPFGHAHVVTTTTHKTLRGPRGGMIMTNDEAIAKKINSAVFPGLQGGPLMHVIAAKAVAFGEALQPDFKSYIAAVVENAKVLAATLKERGSDVVSGGTDTHLALIDLTPLGITGRDADEALERAGITCNKNGIPNDPLPPMKTSGIRVGTPAGTTRGFGPAEFREIGNMVADVLDGLAKKGEHGDPQVEADVRARVRTLCARFPIYQG","proteome":"UP000240996","gene":"glyA","go_terms":[{"identifier":"GO:0004372","name":"glycine hydroxymethyltransferase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0030170","name":"pyridoxal phosphate binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0019264","name":"glycine biosynthetic process from L-serine","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0035999","name":"tetrahydrofolate interconversion","category":{"code":"P","name":"biological_process"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"a467f6dfa8ae11c9935b71e94ed54da4f6601504","counters":{"domain_architectures":46777,"entries":17,"isoforms":0,"proteomes":1,"sets":2,"structures":0,"taxa":1,"dbEntries":{"ssf":1,"pfam":1,"cdd":1,"cathgene3d":2,"panther":1,"pirsf":1,"hamap":1,"ncbifam":1,"prosite":1,"interpro":7},"proteome":1,"taxonomy":1,"similar_proteins":46777}}}