{"metadata":{"accession":"A0A2R9B063","id":"A0A2R9B063_PANPA","source_organism":{"taxId":"9597","scientificName":"Pan paniscus","fullName":"Pan paniscus (Pygmy chimpanzee)"},"name":"Programmed cell death 1 ligand 1","description":["The PDCD1-mediated inhibitory pathway is exploited by tumors to attenuate anti-tumor immunity and escape destruction by the immune system, thereby facilitating tumor survival. The interaction with PDCD1/PD-1 inhibits cytotoxic T lymphocytes (CTLs) effector function. The blockage of the PDCD1-mediated pathway results in the reversal of the exhausted T-cell phenotype and the normalization of the anti-tumor response, providing a rationale for cancer immunotherapy"],"length":290,"sequence":"MRIFAVFIFMTYWHLLNAFTVTVPKDLYVVEYGSNMTIECKFPVEKQLDLAALIVYWEMEDKNIIQFVHGEEDLKVQHSSYRQRARLLKDQLSLGNAALQITDVKLQDAGVYRCMISYGGADYKRITVKVNAPYNKINQRILVVDPVTSEHELTCQAEGYPKAEVIWTSSDHQVLSGKTTTTNSKREEKLFNVTSTLRINTTTNEIFYCTFRRLDPEENHTAELVIPELPLAHPPNERTHLVILGAILLCLGVALTFIFCLRKGRMMDVKKCGIQDTNSKKQSDTHLEET","proteome":"UP000240080","gene":"CD274","go_terms":null,"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"7b38dac28088143820f932a79d156cf7b2e51fe2","counters":{"domain_architectures":6442,"entries":15,"isoforms":0,"proteomes":1,"sets":2,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":1,"ssf":1,"cdd":1,"smart":1,"pfam":2,"profile":1,"panther":1,"interpro":7},"proteome":1,"taxonomy":1,"similar_proteins":6442}}}