{"metadata":{"accession":"A0A2R6BHB0","id":"A0A2R6BHB0_9ARCH","source_organism":{"taxId":"1978161","scientificName":"Candidatus Marsarchaeota G2 archaeon ECH_B_3","fullName":"Candidatus Marsarchaeota G2 archaeon ECH_B_3"},"name":"DNA polymerase beta","description":["Repair polymerase that plays a key role in base-excision repair. During this process, the damaged base is excised by specific DNA glycosylases, the DNA backbone is nicked at the abasic site by an apurinic/apyrimidic (AP) endonuclease, and POLB removes 5'-deoxyribose-phosphate from the preincised AP site acting as a 5'-deoxyribose-phosphate lyase (5'-dRP lyase); through its DNA polymerase activity, it adds one nucleotide to the 3' end of the arising single-nucleotide gap. Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases. It is also able to cleave sugar-phosphate bonds 3' to an intact AP site, acting as an AP lyase"],"length":564,"sequence":"MDNQEIAGILEEYAELLELNGEDVFRVNAYRRAAKSLRNLNTDVVELWRSKRLKEVPGVGRAIAEKIDEIISTGRLRALEELRARIPSEVVELTGVPFVGPKTAKLLYTKFGVSSRAQLIEKLRDGSLVKQGFSPKLAEKILGAVEGVGEAFTKMLLIEGMNEASQLIDKIRGAEFELYVCGSIRRGKEAVGDVDVVVLSKTRDKTLLDLASKLRGGKTLAEGESKLTWVSLRGVQFDFRLAHPEYLGAMQLYFTGSKEHNIALRTHAQRLGFKLSEFGLFEQNGVRVAGASEEEVYSKLGLQYIEPELRENTGEIEAASKGVLPKLADASDVFGDYHVHSTWSDGVDTLERMVEGALRQGYKYVVFTDHSKSERVANGMSEERLRKQAEEIERLRSKYGSIEILHGSEVDILSGGRLDYDDRTLAQLDYVVASLHRRFTSDTEALTEAVIKALENRYVDTVGHPTNRMLGRRPENGVDLEKVLAAAKKNSKFLEVDGQPRRMDLPSIWVKRAVEEGVRLVLSSDAHSTAELGYMMFALINARRGWAAAQNIANSSHKFRSART","proteome":null,"gene":"B9Q07_10875","go_terms":[{"identifier":"GO:0003677","name":"DNA binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0003887","name":"DNA-directed DNA polymerase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006281","name":"DNA repair","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0003824","name":"catalytic activity","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":4,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"b375f0577b909128d4198741efdb9feacb1f801f","counters":{"domain_architectures":441,"entries":38,"isoforms":0,"proteomes":0,"sets":5,"structures":0,"taxa":1,"dbEntries":{"pfam":5,"ssf":3,"cathgene3d":5,"smart":3,"cdd":2,"pirsf":1,"ncbifam":1,"panther":1,"prints":1,"interpro":16},"proteome":0,"taxonomy":1,"similar_proteins":441}}}