{"metadata":{"accession":"A0A2K6LB50","id":"A0A2K6LB50_RHIBE","source_organism":{"taxId":"61621","scientificName":"Rhinopithecus bieti","fullName":"Rhinopithecus bieti (Black snub-nosed monkey)"},"name":"von Hippel-Lindau disease tumor suppressor","description":["Involved in the ubiquitination and subsequent proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Seems to act as a target recruitment subunit in the E3 ubiquitin ligase complex and recruits hydroxylated hypoxia-inducible factor (HIF) under normoxic conditions. Involved in transcriptional repression through interaction with HIF1A, HIF1AN and histone deacetylases. Ubiquitinates, in an oxygen-responsive manner, ADRB2. Acts as a negative regulator of mTORC1 by promoting ubiquitination and degradation of RPTOR"],"length":213,"sequence":"MPRRAENWDEAEAGAEEAGAEEYGPEEDGREESGAEESGPEGSGPEELGAEEEMEAGRPRPVLRSVNSREPSQVIFCNRSPRVVLPVWLNFDGEPQPYPTLPPGTGRRIHSYRGHLWLFRDAGTHDGLLVNQTELFVPSLNVDGQPIFANITLPVYTLKERCLQVVRSLVRPENYRRLDIVRSLYEDLEDHPNVQKDLERLTQEHIANQRMGD","proteome":"UP000233180","gene":"VHL","go_terms":null,"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"f4ef6c96c1bdc72f84e20a3142f24aaebb85f0cd","counters":{"domain_architectures":911,"entries":12,"isoforms":0,"proteomes":1,"sets":3,"structures":0,"taxa":1,"dbEntries":{"ssf":1,"pfam":2,"cathgene3d":2,"cdd":1,"interpro":6},"proteome":1,"taxonomy":1,"similar_proteins":911}}}