{"metadata":{"accession":"A0A2I4CKS2","id":"A0A2I4CKS2_AUSLI","source_organism":{"taxId":"52670","scientificName":"Austrofundulus limnaeus","fullName":"Austrofundulus limnaeus (Annual killifish)"},"name":"Transforming growth factor beta-1 proprotein","description":["Required to maintain the Transforming growth factor beta-1 (TGF-beta-1) chain in a latent state during storage in extracellular matrix. Associates non-covalently with TGF-beta-1 and regulates its activation via interaction with 'milieu molecules', such as LTBP1, LRRC32/GARP and LRRC33/NRROS, that control activation of TGF-beta-1. Interaction with integrins (ITGAV:ITGB6 or ITGAV:ITGB8) results in distortion of the Latency-associated peptide chain and subsequent release of the active TGF-beta-1","Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively"],"length":474,"sequence":"MDLRVKAVAMRFGFVLLVAAQMLDTMSGMSTCKTLDQEIVRQKRIEAIRSQILSKLRLPKAPEANETGDKEEIPTSLLSLYNSTKDMLKEQQIEVQSTISPEQEEEEYFAKVLNKFNMTTTNLTDSSKIMFFNMSEVRRSVGDAALLTSAELRMLIKNTRVREEQRVELYYSSGGSPRYHASRFITNSMKEKWLSFDVTEPLQHWLQQTEEEQSFQLRVFCECGQPGSIFSFSISGTDHIRGDTATMRQRSEQPPYVLTMSIPQNMSARFITNSMKEKWLSFDVTEPLQHWLQQTEEEQSFQLRVFCECGQPGSIFSFSISGTDHIRGDTATMRQRSEQPPYVLTMSIPQNMSARLTSRTKRSTAAQETCTAQTETCCVRSLYIDFRKDLGWKWIHKPTGYHANYCMGSCTYIWNAENKYSQIMALYKHHNPGASAQPCCVPQALEPLPILYYVGRQHRVDQLSNMIVKSCRCG","proteome":"UP000192220","gene":"tgfb1a","go_terms":[{"identifier":"GO:0008083","name":"growth factor activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0005615","name":"extracellular space","category":{"code":"C","name":"cellular_component"}},{"identifier":"GO:0005576","name":"extracellular region","category":{"code":"C","name":"cellular_component"}},{"identifier":"GO:0005160","name":"transforming growth factor beta receptor binding","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"3cbb0d77e515dc60d80b6c4a91c3c776025269b4","counters":{"domain_architectures":116,"entries":20,"isoforms":0,"proteomes":1,"sets":4,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":2,"profile":1,"ssf":1,"cdd":1,"pfam":2,"smart":1,"pirsf":1,"panther":1,"prints":2,"prosite":1,"interpro":7},"proteome":1,"taxonomy":1,"similar_proteins":116}}}