{"metadata":{"accession":"A0A2D0RGN8","id":"A0A2D0RGN8_ICTPU","source_organism":{"taxId":"7998","scientificName":"Ictalurus punctatus","fullName":"Ictalurus punctatus (Channel catfish)"},"name":"S-adenosylmethionine sensor upstream of mTORC1","description":["S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 signaling. Probably also acts as a S-adenosyl-L-methionine-dependent methyltransferase"],"length":407,"sequence":"MRHSRIPVVRELQQHGHYSVSAMELQPSVRTEPEPGMFHSAGRRDALCERDEQEKLSGVVKRVHRKLRRKYIEVGDFDKIWREHCEDEQTLNEYAFAMKSLADNHWAKKCDGEGRIEWCRSVCQEYFMDGGMKKMLEKDAKHAAAASGTPLNPDSSQPSLSFRNDKLRLLDVGSCFNPFLKFDEFFTVGIDIVPAVESVYKCDFLNLQLQQPLQLASDALNAFLRQLHDPIETLPGQLFHVVVFSLLLSYFPSPYQRWLCCKKAHELLTLHGLLLIITPDSSHQGRHALMMRSWRVAVESLGFRRYKYVKFSHMHMLAFRKVSVTTSSDLVSHNYPEMLYIPQDFGTLEEDDAFRDSYQPARSDSEDEQLARSFTELPDVSYDSDSGESQSGSAPFYELEDPILLYS","proteome":"UP000221080","gene":"bmt2","go_terms":null,"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":null,"counters":{"domain_architectures":0,"entries":5,"isoforms":0,"proteomes":1,"sets":0,"structures":0,"taxa":1,"dbEntries":{"ssf":1,"hamap":1,"panther":1,"interpro":2},"proteome":1,"taxonomy":1}}}