{"metadata":{"accession":"A0A2D0PMW5","id":"A0A2D0PMW5_ICTPU","source_organism":{"taxId":"7998","scientificName":"Ictalurus punctatus","fullName":"Ictalurus punctatus (Channel catfish)"},"name":"Nucleolysin TIAR","description":["RNA-binding protein involved in alternative pre-RNA splicing and in cytoplasmic stress granules formation. Shows a preference for uridine-rich RNAs. Activates splicing of alternative exons with weak 5' splice sites followed by a U-rich stretch on its own pre-mRNA and on TIA1 mRNA. Promotes the inclusion of TIA1 exon 5 to give rise to the long isoform (isoform a) of TIA1. Acts downstream of the stress-induced phosphorylation of EIF2S1/EIF2A to promote the recruitment of untranslated mRNAs to cytoplasmic stress granules (SG). Possesses nucleolytic activity against cytotoxic lymphocyte target cells. May be involved in apoptosis"],"length":346,"sequence":"MMSDDDQPKTLYVGNLSRDVTEALIMQVFTQIGPCKSCKMILDTAGNDPYCFVEFFEHMHAAAALAAMNGRKILGKDMKVNWASMPSSQKKDTSNHFHVFVGDLSPEISTEDVRAAFAPFGKISDARVVKDLATGKSKGYGFISFINKWDAENAIQQMNGQWLGGRQIRTNWATRKPPAPKSNLESQSGTGNTKHLSYEEVLNQSSPSNCTVYCGGVTSGLSDQLMRQTFSPFGQIMEIRVFPDKGYSFVRFDSHESAAHAIVSVNGTCIEGHTVKCYWGKETADMRAMQQMAMPQQSNPAYAAQPYGQWGQSYGNGQQMGQYVPNGWQMPTYGVYGQAWNQQGYK","proteome":"UP000221080","gene":"tia1l","go_terms":[{"identifier":"GO:0003676","name":"nucleic acid binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0003723","name":"RNA binding","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":4,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"1d8d02f5f54dae87c0a5dfa9c17a8ccb9f1ee753","counters":{"domain_architectures":50304,"entries":12,"isoforms":0,"proteomes":1,"sets":2,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":1,"ssf":1,"profile":1,"smart":2,"pfam":1,"cdd":1,"panther":1,"interpro":4},"proteome":1,"taxonomy":1,"similar_proteins":50304}}}