{"metadata":{"accession":"A0A2A9MG32","id":"A0A2A9MG32_BESBE","source_organism":{"taxId":"94643","scientificName":"Besnoitia besnoiti","fullName":"Besnoitia besnoiti (Apicomplexan protozoan)"},"name":"E3 ubiquitin-protein ligase","description":["Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation"],"length":5342,"sequence":"MDSPSAPHDREAPAPPRRSDPRGAQGSESPTAVRASSISRPHAPPGTPAASRLEEATISSHGAGAAATAASDVAETGLRRSVEAPEGEASTPASAAAASRSSTASPPCPRTADGELLGMPGAPGAPGDRDTELWLFYPAAAAPERDLDSASSSAFVAASSQAPHDTTSSASSASSSSLSSPDPQSSDDAGGAPRLPAGVAPSSQPLAARLPSPSLFAALAPSCVSASRAPAPPASPSSTEGPPPGLSSTGAVFLPSYPPLPTFSDDMRVFASKAQLVHLLRVCQGHLELLDAAFLEERRRRRREASAPCSAAPAMLWCPQISRASLPTLVDALEASSGSLVQMGHRLDSLLARASHATLLLATAVIVEQLQDPELLLSLFCAVFASLGDTEAYQRLLPCIAPFSELLPSSSAPFASSSSSASPSSGADSSLGGASASAAPSVYACPLPVSTVPFASLDSAPSSFLTAAAAAFLSRLPALPHARSRCGQVWDGEHVAYRCLTCGGSQSSCICVFCFQEGSHLGHSYFIYRSSCGGCCDCGDASAWAPSGFCRHHPGSRRDVDPSVALPASSKFALVLLLRVLVRRLAMHALEKNWTATRELCETLLQLSEQHEGIRRCVGRAMLEAVRGTPEDSLGFADSAKPGEGRLWLPPNYARYDSWQSLLLNKALVPTAFASSPSSPGGSASPSMFSEEEELATRAAEGAARAAEAAEMAERSAAGGTWGLLGSEEGERRMLAATARELAEIEERKKAGGVNVKAFDDALKFAIWGDASHRQRVLRSGDETEGADGVKEERKREAEQPAREKEEAKTQRPKEPDRSDKRQRDGDQKRDADVGEGARERGAESAAGTLLAPRQFGVGACVASVLLKVACDISGRLADDEDEGRRREETRERDEAKTEKAVHASLTTLWLALMFDEWFKEQFAFVFIQQYRDLVLKSDSALERVTVQVLSIRSLLTRLLYSGVLLPRLFSACRLVLAQAVPLLLPTHHADRGLFSRTRKRCSWRGYPSPPYIDVRNSLLHRRGYTNSLNDVRYLVAEKDLLIQYLSEHPAHVAAMWDDGFLPLYCLSQNVNLHRRRTKLHVEYEDSHRWSHSLCLAIELGQNALALHDILEACPWPVAVLIFQKARQRLHAWIGATRRREGLEEGVRWVFASQGGVAKLLQREREKHQRARAAADQEGRAAPGEADADEEAETQRRDTRPPYPEARSLDHVVSRHPTSFHVPLNRLFAQLLKALMSHKDCPVGTLEELLDLLGVSLEDRMEVLEHHLRTLVFYHQVTTCSMWIRNGLTVMSEAQCYRRTFYQSVLIDLDLTAARIGCCSIPPPLLLLHLLARCEVPYDLSLSSAGSSLLLPLSLPSSSPRASASLSSAGASASPASAEGSAAAPEDSARPQQVASPASSSLAEGAASDPPGLQVGVVCASTEPWMEDIALVAPVAARGPAPYLPPSRRRRHAEELGEGRSLARRREAMIDEVLFGGRTAEHLLPQTHAFMVLLLQFLNPTNSLFCSEEEVMTYLLRHHLMRGPQTHSNLQDVVTRPHKQQPQFTDLVDRVLKRISTYRAAEGMTPGQFHIHPSSWAFYDPYFPYFSWADHQHIEEAFLEQIKAHPEVLNNWLPRPSLPPADAAAPSTSKSASTSSPSSVPVAYRSSFFAFCLSPVVRSAAWLLTLQVLLSQASDHRFIHLLLSLLLRLMSLEILWKEQEPPEARARLRAELRRGDLLRGVLARRRSRKRPLAAEEGAEASDAGAEGVSCSDEEREKAEEDGVVIELREDVDLLGLARWMGVNLGDSLLRMFQLRHVFQDVTGQEEARWFSARFASASGSKRREDRGASARPSRRERGASASSSSSSPSSAAHTSAYWAAEALKTEGEDEGGERARQRENGCEHDAEADEGAAAASSAEETSAGAHSDDEEEDEARDEEKIAGRGDLAKTKHGEKRTESFTTATEGGFPQSESASADFGWLCEENPRDDEGDFWAESASMRPVLEAAGEAPEARSALRGERMRTRGRQVGSRRRTREDAEAERSALRLRAAMLWETGRGVFFPDDEEEEELSSSDSEGDRDELVACREGAASQESDQEDDDMAAYIDWGYGPRGGEAPGARRQESGEEDVEMTAHRGEDADDGRLRRGAAQDAVSSSSSRGPPAPPRPATPEALGTAESPGDASRTLPVSLLEAEGALAAAASQPSSSSPSLLAPHPRAEADEAEDAREGALGAGKDSPTARAASPEGGDEERRSMRGWRRRRRRVGTAWATTAKGVEGLLDLLGQDAFVVDAASSLGASEGDPSPRREKEENGEARLIVAETGEILYDRDDAGAPWSVFSDPLLLALHRLKKEELERHSGGVAAASPAALSLQAASSLSASDSSPSEAPGAAASALEARSASPAFSPFPSGFHVEAVADPQGASAASALFASARENDFCLRAGAAGEVARRLLDKMQRRPDFTRSSAARGRAATHAAKTEKRGGEEPVSAAPEVDSSNLDGETSQKAREFAAHVLPSASASLSSSSSSSSSAASSPSALASSHAASSPALSSSSWLEQTTAAARTAAIEAGDLAPVPLSEGSSLSALRSFADLFRRPSAAAQPADVASPASSTDASLTTASGSGPAASSSAAAERIGDGLGSFAATLRQHFADILQGGASDDRGEDPREEASSPSSSSSVASAAGPRAAASRRAANRSGQRHRAEGELALSASASSRAGADSQERTRGEAAAGEAEGEEDDDEEFEEEGVLRLEAPEDFPGSGSWQVTLLRAVVGGAQSAERNLANLQVVARRLLRGADDEDEDGQAAVLRTRSGSVSIVLGRRAPAAGAGGGSASAKSRRREGQARENAKKKEICDALLRLIRGRKRAPPEFPFLIRFSMLQILFAMRHCPRYEAHWQQLDWVLQSAARLDSRVARRLRRWKRAMATAVATDAPIPTTVLRARPGAVPSLGLPKRKICAESDERRGEAKKASSSFACRGDDGAESALEDVEEGDDVCMEGDDRRGDRQGPSGPRAGAGDGGDGEEAIPAAGGSGGLQDEAAEDAKRGEEWKEAVRRRQEQVLAAYRQQQEAFQSGNQRDFDEAKFLADSDVPRCVSCRLEEETLLSFLSSSGSPLSEDYERIFGAAARCSSPFNSPGTDPLGLLCHVQLTAVGNAPRPSIPPCLLQPPWAVAAYGASAGGGAAGDTGRAAAARAAGAAGSRDGAPAAGGAPRSRSGSGSAAGAGAAGGAVASGLGPLSGSGVDGALGALARASGREPGGAEEALEGGESRLAALGLSGDQLEHVDDGMFDAEAAAEILDGVASPASFSYDLVPNLLSPLGAFQGFQIRSCGHRIHLSCYRLYQKSQRHHLYLSQLLLPCPYCHQPCNLLLIDAPPPAVARLQLHGLLTAQVRKATLALTDGTAASATGGACEAGARDQEVSRRETKAAASPALSAAPTPPDRTYGGLATPSARAIAGGPAPFGRGDGSAKAGARGESPDAALSPSAADDDGASTPAAVSWTVTLGRFVRRCEKLREQRRVLAPLLCPPSSMRHDRPPLPSSSPLLLQAPMLQTPAGSDLLHLCRASLRISPIHLPAPVLWSPSPTTLWRSSGSIGPSGATFDAAILFSDLAAFPPRTAEASSFGLAGRSLFSRAPLSRGRTARTPVAVSPPKCLQLAVPAWGHPEGLGIQGPTGVRDGAGLDGESQRPRDRRTGGHGERSPEVPAEGEDKKGAKQDVASGSEEEGHMEECSEDVDVPSESSRGDTVGERPYGTDAAGDERAPTPPAEASGACTTPGLSPSPSSAAAACSSGSSSSCLEPSSLESEGAGGRAGGDGRLDDGGCLFWTPQDVSRLYGHAAASAQQEGGGALPRNDFVVHPLAVVSKLISDSVEHTEMVLRSRPQGEQGLSSWRSEVLHGSYAVYLHMAEELQHVAVGDAGVTAFDVYLHDLELMALFHCPLFPSLLGQPIVAAPPTGSPPSSRSLRSPVSGGRPSSVSSATQGGFSSSASTVSPLSPAPAAGGVLPSDACAYVDLVLSLSLMQPATRFHLLTRLFLAFHAQALAAKAEESAGGVGRHLRAAIEAAERGARAAERFLLGPAAASPGASAAPRRSPSSSEASGESARSQRVSDAPVAAQAGLLDTDAEEAEREEERDLDAEEEGRSRARGAGARRRSSGADAEPSERRGTEGEGWRSLATVLQEIEEEIAAALGAEGEQASQAASQGSAGARPAAEEEETMNPGGDQEAQTAAPASGMSASSQSAAVHAAGIDRAKGARGAPAASASTKATRRQRAHLETLELYVQLFFLSEVVAILWQWWDRLPFLSAEWSLPSQGEKGDEAEAPAWREIWRVLRRRAKQQRDARLLPKVLELSAASPSSLASRGRRGLSTPLERVQAEPTPPMRAADGHAGGLPQLALATVGASHASPGAAERADAETASGDSGRPQCESRREEEEEKAEKTTSKRRSTSRKTEEDEGADGTDESGRRRRKRNCEDDAGTGGGGTHGAGRNDAHRQDAFLEAARGEAGDAAASMHTEEEGERRGRLGGASPGLSTPGHPAESGRKERTEGQGAPRRAEPSDGGSAKQKACTREREEERERRQTRGDGLFARRAHAASQRLITLWNEEVEAEPLEWESDMAVLEETRRADGVSAGVWLEDLRLLGRRLPYSLRKEQLGVAAWRVRFGVDRDCKRRHSDGRGPAEDRGEGAADDDSTRRSGHAFADEESAEEDNLALTKEYLLSVYAARAERAAELKGASQASWLHPTAALSRASLGGLKPSLVDRVSPPFGLLEAPGAFAVADEQAEGPEDAHKLKGENAGETGFEPATGGMSEDDRKQVITRVVEAGLVPWLRKLHLLAKVVYPEHALPFEEIKTTYEMLGPASASDAPVLHTAPLPAWLPSSSAPAPLFEPRASPAASASLSDLLPAGMELYDPAEECSILLEALPLPRSVRGFLFGDDEEEPWGADAAAAERMRMEKEEELASDREQVAAALGPSRGGAGWPHGVSEARALRLLLQESQLLCCLSAMPPCATSLTTLVPIVVSSRAGHELLLRLFQDSLRLALTEKSGQALPPPSSLLWAAPLSSARPLSLSSSSSPTLSPTVSPFFFPAAGCAPGAFLLESLVSPVAEARGGDADALRQAAAALDTYTVYFHPLTRRLLPEDLASFIAATRMKCTLLFSTARKGGRRRDGSATDGEDQRFTAVYVAQFLPHHTFLPKLYQQFYNHFLQLGAYTPEVGLHATPSCAVCVSCGAFLCALDCCDAKVSVRGASRLPNRVMNLRRHAITCGMGLGLYLHLSASAVYTAAVDTAVDRDAKWGCLHLDAYGEEDPLLKRGKPLHLSLNRLARLTDDWRQHQIRLLRRLQWSRMDSSSTNHAAQGM","proteome":"UP000224006","gene":"BESB_065900","go_terms":[{"identifier":"GO:0008270","name":"zinc ion binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0061630","name":"ubiquitin protein ligase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0071596","name":"ubiquitin-dependent protein catabolic process via the N-end rule pathway","category":{"code":"P","name":"biological_process"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":false,"ida_accession":"469f8bf5a8edcc0c8fae00bfc54ff0f44a9b7b2b","counters":{"domain_architectures":908,"entries":14,"isoforms":0,"proteomes":1,"sets":4,"structures":0,"taxa":1,"dbEntries":{"cdd":1,"smart":1,"profile":1,"pfam":4,"cathgene3d":1,"panther":1,"interpro":5},"proteome":1,"taxonomy":1,"similar_proteins":908}}}