{"metadata":{"accession":"A0A287AGF8","id":"A0A287AGF8_PIG","source_organism":{"taxId":"9823","scientificName":"Sus scrofa","fullName":"Sus scrofa (Pig)"},"name":"Elongation of very long chain fatty acids protein 2","description":["Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C20:4(n-6) acyl-CoA. Condensing enzyme that catalyzes the synthesis of polyunsaturated very long chain fatty acid (C20- and C22-PUFA). May participate to the production of polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators"],"length":318,"sequence":"GLSPFSGERLSLSRSWSSFVYIHEHLKAFDDEINAFLDNMFGPRDSRVRGWFMLDSYLPTFVLTVLYLLSIWLGNRFMKSRPALSLRGLLTFYNLGITLLSAYMLAELILSSWEGGYNLQCQDLTSAGEADIRVARVLWWYYFSKLIEFLDTIFFVLRKKTSQITFLHVYHHASMFNIWWCVLNWIPCGQSFFGPTLNSFIHILMYSYYGLSVFPSMHKYLWWKRYLTQAQLVQFVLTITHTLSAVVRPCGFPFGCLIFQSSYMLTLVILFLNFYVQTYRKKPMKKDTDAPPAGKEVKNGFSKVYFTATNGAINKKAQ","proteome":"UP000008227","gene":"ELOVL2","go_terms":[{"identifier":"GO:0009922","name":"fatty acid elongase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0019367","name":"fatty acid elongation, saturated fatty acid","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0042761","name":"very long-chain fatty acid biosynthetic process","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0005783","name":"endoplasmic reticulum","category":{"code":"C","name":"cellular_component"}},{"identifier":"GO:0016020","name":"membrane","category":{"code":"C","name":"cellular_component"}}],"protein_evidence":1,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"726b44df556ad17af08cf1eeb76a7efce6e198bf","counters":{"domain_architectures":25966,"entries":7,"isoforms":0,"proteomes":1,"sets":0,"structures":0,"taxa":1,"dbEntries":{"hamap":1,"panther":1,"pfam":1,"prosite":1,"interpro":3},"proteome":1,"taxonomy":1,"similar_proteins":25966}}}