{"metadata":{"accession":"A0A286XBS2","id":"A0A286XBS2_CAVPO","source_organism":{"taxId":"10141","scientificName":"Cavia porcellus","fullName":"Cavia porcellus (Guinea pig)"},"name":"E3 ubiquitin-protein ligase LNX","description":["E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of NUMB. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates ubiquitination of isoform p66 and isoform p72 of NUMB, but not that of isoform p71 or isoform p65","Isoform 2 provides an endocytic scaffold for IGSF5/JAM4"],"length":624,"sequence":"MKALLLLVLPWLSPANYIDNVGNLHFLYSELCKGASHYGLTKDRKRRSQDGSSDGCASLTATPLSPEVSEAPHEPGLDDPSCMSTVENCHPENSSSDTGRSNRTRAWPFERSSFRIRSFKKLNRAFSSLRRTKNGSIIANCADQSRENHENTTVPEVFPKFYHLIPRGEVTSIKINRVDPNESLSIRLVGGSETPLVHIIIQHIYSDGVIARDGRLLAGDIILKVNGMDISNVPHNYALNLLRKPCQVLWLTVLREKKFQSKRHAHSLYFCGPRNDSFQVILNKSSPEEQLGIKLVRKVDEPGVFVFSLLNGGVADRHGQLQENDRILAINGHDLRNGNPEIAALLIQASERRVHLVVSRQAREQSPVTCQEASRTHSSGQSPGPGDITPKPFCSAAVCHEKLVSVRKDPSESLGMTVAGGTSPREWDLPIYVISIEPGGIISRDGRIKTGDILLNVNGVELTGVTRSEAVALLKSSSSSVVLKALEVEEHVPQENCNGPEALDCIYNMSPPDVWSPSWVTWLELTQYLYNRKDVVLRRNIAGTLGFRIVGGYEENNGNKPFFIKSIVEGTPAYKDGRIRCGDILLAVNGRSTSGMMHAFLTRMLKEIKGRITLTIVSWPGTFL","proteome":"UP000005447","gene":"LNX1","go_terms":[{"identifier":"GO:0005515","name":"protein binding","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":4,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"3bb909df24b168eae25613c09d851f8b7fd7954b","counters":{"domain_architectures":3298,"entries":13,"isoforms":0,"proteomes":1,"sets":1,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":1,"ssf":1,"cdd":4,"profile":1,"pfam":1,"smart":1,"panther":1,"interpro":3},"proteome":1,"taxonomy":1,"similar_proteins":3298}}}