{"metadata":{"accession":"A0A286U7X0","id":"A0A286U7X0_9AGAM","source_organism":{"taxId":"2282107","scientificName":"Pyrrhoderma noxium","fullName":"Pyrrhoderma noxium"},"name":"DNA polymerase beta","description":["Repair polymerase that plays a key role in base-excision repair. During this process, the damaged base is excised by specific DNA glycosylases, the DNA backbone is nicked at the abasic site by an apurinic/apyrimidic (AP) endonuclease, and POLB removes 5'-deoxyribose-phosphate from the preincised AP site acting as a 5'-deoxyribose-phosphate lyase (5'-dRP lyase); through its DNA polymerase activity, it adds one nucleotide to the 3' end of the arising single-nucleotide gap. Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases. It is also able to cleave sugar-phosphate bonds 3' to an intact AP site, acting as an AP lyase"],"length":833,"sequence":"MNFVEKQRLLAGIPDEDFDEFRAQKRRRLQSEQKSSKLSTDSISISQSLVHPNLLSQQTEPEKSRNEPRSDSINAETNEQLQSLTGQASDDRQYSQPNPMEVDQSYQSSPKGRSLSRSISPPQPLLDTVSSDNILPSSLSRPEAKQQDEPSTISEPNSSNLRQNHGEASINNQQHDDVPQQSTENQDSEKMNTSIVTDITSPSNSPAVPLLRVTPRPRQTLESKRKMKAKKTSEMALKKKEEEEEKRMTPREYATKVQEKFKDELKKASEKELFLKNKTIFYVGGDYDKAVRSTRSRMDYLRKKGATVAPVYDPNTVTHIITDTNAKITLKALGLKSLDEIPFHIPTLRWTWISNRSDHHLFLHAAFAKRIDCGPEEVYPVPKRKKKDTRQAQDDWEFSRIEEFPTSLHEVPATNEGSSKTGQLIDVDLSTVAKKTADNDSTLHEFNIICDMVRGNQDLEFSDSAEENNVEGPSSLTDKAKPVFTCDRLNGDKKACPNQDVVDKLEALRKINEGKPSKQGDEQHWRLFSYGKSIAALKRYPKRIQSLEEAKSIKGVGEKTARKIMEIIRTGDLQRITYDNTEQVQVSNLFKGVYGVGSSTAYTWYSMGCRTLEDLEQRKGGVKLTDAQQIGLEHYEDINTRIPREEVTEIFNSIKKIALSIDPNLFVEVMGSYRRGKETCGDIDILMTRPTYDGRDHRGMLGILLKKLHEQKILTEDLAIPEDMEDLELTYRGLCRHGGNGRRRRIDILVIPWQYRGAALLYYTGDDIFNRAMRFKAKKMGYSLSQRGLSAGVLRNQRGKKLVPGKIIASETEEEIFRILDVPWQEPYERVRS","proteome":"UP000217199","gene":"PNOK_0851300","go_terms":[{"identifier":"GO:0003677","name":"DNA binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0003887","name":"DNA-directed DNA polymerase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006281","name":"DNA repair","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0034061","name":"DNA polymerase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0016779","name":"nucleotidyltransferase activity","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"5fd7183be16cdf978797e5c747a48dff9c92f31e","counters":{"domain_architectures":4883,"entries":32,"isoforms":0,"proteomes":1,"sets":3,"structures":0,"taxa":1,"dbEntries":{"profile":1,"cathgene3d":4,"ssf":3,"pfam":4,"smart":2,"cdd":1,"panther":1,"prints":2,"prosite":1,"interpro":13},"proteome":1,"taxonomy":1,"similar_proteins":4883}}}