{"metadata":{"accession":"A0A250XV93","id":"A0A250XV93_CASCN","source_organism":{"taxId":"51338","scientificName":"Castor canadensis","fullName":"Castor canadensis (American beaver)"},"name":"ADP-ribose glycohydrolase OARD1","description":["ADP-ribose glycohydrolase that hydrolyzes ADP-ribose and acts on different substrates, such as proteins ADP-ribosylated on glutamate and O-acetyl-ADP-D-ribose. Specifically acts as a glutamate mono-ADP-ribosylhydrolase by mediating the removal of mono-ADP-ribose attached to glutamate residues on proteins. Does not act on poly-ADP-ribosylated proteins: the poly-ADP-ribose chain of poly-ADP-ribosylated glutamate residues must by hydrolyzed into mono-ADP-ribosylated glutamate by PARG to become a substrate for OARD1. Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins. Catalyzes the deacylation of O-acetyl-ADP-ribose, O-propionyl-ADP-ribose and O-butyryl-ADP-ribose, yielding ADP-ribose plus acetate, propionate and butyrate, respectively"],"length":152,"sequence":"MASSLNEEPDGSRITYVKGDLFACPRTDSLAHCISEDCRMGAGIAVLFKKKFGGVQELINQQKKSGEVAVLKRDGRYIYYLITKKRASHKPTYENLQKSLEAMKSHCLKNGVTDLSMPRIGCGLDRLQWENVSAMIEEVFEATDIKITVYTL","proteome":"UP001732720","gene":"OARD1","go_terms":null,"protein_evidence":4,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"e5ac68d3438d6b05a70a28eff72efc14305c5af4","counters":{"domain_architectures":26011,"entries":10,"isoforms":0,"proteomes":1,"sets":2,"structures":0,"taxa":1,"dbEntries":{"profile":1,"cathgene3d":1,"smart":1,"cdd":1,"ssf":1,"pfam":1,"panther":1,"interpro":3},"proteome":1,"taxonomy":1,"similar_proteins":26011}}}