{"metadata":{"accession":"A0A226CZB8","id":"A0A226CZB8_FOLCA","source_organism":{"taxId":"158441","scientificName":"Folsomia candida","fullName":"Folsomia candida (Springtail)"},"name":"2-oxoisovalerate dehydrogenase subunit beta, mitochondrial","description":["Together with BCKDHA forms the heterotetrameric E1 subunit of the mitochondrial branched-chain alpha-ketoacid dehydrogenase (BCKD) complex. The BCKD complex catalyzes the multi-step oxidative decarboxylation of alpha-ketoacids derived from the branched-chain amino-acids valine, leucine and isoleucine producing CO2 and acyl-CoA which is subsequently utilized to produce energy. The E1 subunit catalyzes the first step with the decarboxylation of the alpha-ketoacid forming an enzyme-product intermediate. A reductive acylation mediated by the lipoylamide cofactor of E2 extracts the acyl group from the E1 active site for the next step of the reaction"],"length":380,"sequence":"MLHRTLLRSATITLRNSKFQKLQNADNFLSSPKVFSRLSSHFTYVPDTVSPSEGETVRMNMFQAINNAMDIAMTSDPSAVIFGEDVAFGGVFRCTLNLQEKHGKDRVFNTPLCEQGIAGFAIGLAVSGSTAIAEIQFADYIFPAFDQLVNEAAKFRYRCGNQFDCGKMTIRSPCSAVGHGALYHSQSPEAYFAHTPGLKVVIPRSAVKAKGLLLSCIRSPDPCIFFEPKILYRTAVEMVPSKDYEHPIGKADILIEGDTVTLVGWGTQVHVLREVAQLAQDRLNVSCEVIDLVTIAPWDKETIYNSVKKTGRLVIAHEAPLTSGFGAEIAASVQKDCFLQLEAPVQRVAGHDTPFPHVFEPFYLPDKWRCLEAVRVAVEF","proteome":"UP000198287","gene":"Fcan01_27287","go_terms":null,"protein_evidence":4,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"4347a88d8b8d5a4cc8b0ce107fb03375ff211f8d","counters":{"domain_architectures":52316,"entries":13,"isoforms":0,"proteomes":1,"sets":3,"structures":0,"taxa":1,"dbEntries":{"ssf":2,"cathgene3d":2,"pfam":2,"smart":1,"cdd":1,"panther":1,"interpro":4},"proteome":1,"taxonomy":1,"similar_proteins":52316}}}