{"metadata":{"accession":"A0A1W7CTX4","id":"A0A1W7CTX4_9ACTN","source_organism":{"taxId":"2878388","scientificName":"Streptomyces marincola","fullName":"Streptomyces marincola"},"name":"Formamidopyrimidine-DNA glycosylase","description":["Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates"],"length":290,"sequence":"MPELPEVEVVRRGLARWVGGRTVEAAEVLHPRAVRRHLAGAEDFADRMRGMAVTDVRRRGKYLWLPFENGVALLAHLGMSGQLLVHQERAPDEKHLRVRVTFTDLARGELRFVDQRTFGGLSLHPLTEAGVPDVIGHIARDPLDEEFDEDAFHAALRRRRTTLKRALLDQSLISGVGNIYADEALWRAGLHYDRPTASLSRRGTADLVRHVRDVMTAALAVGGTSFDSLYVNVNGQSGYFSRSLDVYGREGEPCHRCGGPVRRRPWMNRSSYFCPRCQRAPRTGAGAARA","proteome":"UP000194218","gene":"mutM","go_terms":[{"identifier":"GO:0003906","name":"DNA-(apurinic or apyrimidinic site) endonuclease activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0008270","name":"zinc ion binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0019104","name":"DNA N-glycosylase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006284","name":"base-excision repair","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0003684","name":"damaged DNA binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0016799","name":"hydrolase activity, hydrolyzing N-glycosyl compounds","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0003676","name":"nucleic acid binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0008534","name":"oxidized purine nucleobase lesion DNA N-glycosylase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006281","name":"DNA repair","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0003677","name":"DNA binding","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"482ea9e1972ccf3ae16fea46d9abc5af3fa1bd74","counters":{"domain_architectures":10530,"entries":24,"isoforms":0,"proteomes":1,"sets":2,"structures":0,"taxa":1,"dbEntries":{"pfam":2,"cathgene3d":2,"profile":2,"smart":2,"cdd":1,"ssf":3,"ncbifam":2,"panther":1,"hamap":1,"prosite":1,"interpro":7},"proteome":1,"taxonomy":1,"similar_proteins":10530}}}