{"metadata":{"accession":"A0A1U7UYQ7","id":"A0A1U7UYQ7_CARSF","source_organism":{"taxId":"1868482","scientificName":"Carlito syrichta","fullName":"Carlito syrichta (Philippine tarsier)"},"name":"Beta-hexosaminidase subunit alpha","description":["Hydrolyzes the non-reducing end N-acetyl-D-hexosamine and/or sulfated N-acetyl-D-hexosamine of glycoconjugates, such as the oligosaccharide moieties from proteins and neutral glycolipids, or from certain mucopolysaccharides. The isozyme S is as active as the isozyme A on the anionic bis-sulfated glycans, the chondroitin-6-sulfate trisaccharide (C6S-3), and the dermatan sulfate pentasaccharide, and the sulfated glycosphingolipid SM2. The isozyme B does not hydrolyze each of these substrates, however hydrolyzes efficiently neutral oligosaccharide. Only the isozyme A is responsible for the degradation of GM2 gangliosides in the presence of GM2A"],"length":337,"sequence":"MAYNKLNVFHWHLVDDPSFPYESFTFPELTRKGSYNPVTHIYTAQDVKEVIEYARLRGIRVLAEFDTPGHTLSWGPGIPGLLTPCYSGSQPSGTFGPVNPSLNNTYEFMSTFFLEVSSVFPDFYLHLGGDEVDFTCWKSNPDIQDFMKKKGFGDDFKQLESFYIQTLLDIVSSYGKGYVVWQEVFDNKVKVRPDTVIQVWREETPVSYMKELELITKAGFRALLSAPWYLNRISYGPDWKDFYLVEPLAFEGTPEQKALVIGGEACMWGEYVDNTNLVPRLWPRAGAVAERLWSSQLSVDLQFAYLRLSYFRCELLRRGVQAQPLNVGYCEQEFEET","proteome":"UP000189704","gene":"HEXA","go_terms":[{"identifier":"GO:0004553","name":"hydrolase activity, hydrolyzing O-glycosyl compounds","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0005975","name":"carbohydrate metabolic process","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0004563","name":"beta-N-acetylhexosaminidase activity","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"ida_accession":"4017a680ec7ef5e37f2a090c9e96060a949d18c3","counters":{"domain_architectures":5140,"entries":9,"isoforms":0,"proteomes":1,"sets":2,"structures":0,"taxa":1,"dbEntries":{"pfam":1,"cdd":1,"ssf":1,"cathgene3d":1,"panther":1,"prints":1,"interpro":3},"proteome":1,"taxonomy":1,"similar_proteins":5140}}}