{"metadata":{"accession":"A0A1U7U7P0","id":"A0A1U7U7P0_CARSF","source_organism":{"taxId":"1868482","scientificName":"Carlito syrichta","fullName":"Carlito syrichta (Philippine tarsier)"},"name":"Craniofacial development protein 1","description":["Required for the structural stability of pericentromeric heterochromatin. Regulates heterochromatin state by stabilizing CBX5/HP1alpha and H3K9me3 at major satellites and CENPA at minor satellites and is required for incorporation of histone H2AZ1/H2AZ into chromatin. Maintenance of chromatin structure promotes binding of guanine-nucleotide releasing factor RCC1 to minor and major satellite repeats. Chromatin-bound RCC1 maintains high levels of GTP-bound RAN near the centromeric heterochromatin, facilitating RAN-mediated microtubule nucleation during mitosis. Plays a role in craniofacial development. Required to maintain normal cell function in embryonic development"],"length":298,"sequence":"MEEFDSEDFSTSEEDEDYVPSGGEYSEDDVNELVKEDEVDGEEQTQKTKGKKRKAQSIPDRKRKQGGLSLEEEEEDASAESDGSSSEEEDEATEQEKGVGSEDARKKKEDELWASFLNDVGPKSKVPPSTQVKKGEETEETSSSKLLVKAEELEKPKETEKVKITKVFDFAGEEVRVTKEVDATSKEAKSFFKQNEKEKPQAHVPSALPSLPAGSGLKRSSGMSSLLGKIGAKKQKLSTLEKSKLDWESFKEEEGIGEELAIHNRGKEGYIERKAFLDRVDHRQFEIERDLRLSKMKP","proteome":"UP000189704","gene":"CFDP1","go_terms":null,"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"ida_accession":"191cf45561c39fb8a94e635cd9b568a1ef992b51","counters":{"domain_architectures":3632,"entries":5,"isoforms":0,"proteomes":1,"sets":0,"structures":0,"taxa":1,"dbEntries":{"profile":1,"panther":1,"pfam":1,"interpro":2},"proteome":1,"taxonomy":1,"similar_proteins":3632}}}