{"metadata":{"accession":"A0A1U7FLX1","id":"A0A1U7FLX1_SALET","source_organism":{"taxId":"57743","scientificName":"Salmonella enterica subsp. enterica serovar Weltevreden","fullName":"Salmonella enterica subsp. enterica serovar Weltevreden"},"name":"2-methylisocitrate lyase","description":["Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate","Involved in the catabolism of short chain fatty acids (SCFA) via the 2-methylcitrate cycle (propionate degradation route). Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate via an alpha-carboxy-carbanion intermediate","Involved in the catabolism of short chain fatty acids (SCFA) via the 2-methylcitrate cycle I (propionate degradation route). Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate via an alpha-carboxy-carbanion intermediate"],"length":295,"sequence":"MSLHSPGQAFRAALAKENPLQIVGAINANHALLAQRAGYQAIYLSGGGVAAGSLGLPDLGISTLDDVLTDIRRITDVCPLPLLVDADIGFGSSAFNVARTVKSIAKAGAAALHIEDQVGAKRCGHRPNKAIVSKEEMVDRIRAAVDARTDPNFVIMARTDALAVEGLEAALDRAQAYVDAGADMLFPEAITELSMYRQFADVAQVPILANITEFGATPLFTTDELRSAHVAMALYPLSAFRAMNRAAEKVYTVLRQEGTQKNVIDIMQTRNELYESINYYQFEEKLDALYRNKKS","proteome":null,"gene":"prpB","go_terms":[{"identifier":"GO:0003824","name":"catalytic activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0046421","name":"methylisocitrate lyase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0019629","name":"propionate catabolic process, 2-methylcitrate cycle","category":{"code":"P","name":"biological_process"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"c015c03b2a2ce5a822bfed977dd41e4fd38e5984","counters":{"domain_architectures":30121,"entries":14,"isoforms":0,"proteomes":0,"sets":2,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":1,"ssf":1,"pfam":1,"cdd":1,"hamap":1,"ncbifam":2,"panther":1,"prosite":1,"interpro":5},"proteome":0,"taxonomy":1,"similar_proteins":30121}}}