{"metadata":{"accession":"A0A1S2ZN89","id":"A0A1S2ZN89_ERIEU","source_organism":{"taxId":"9365","scientificName":"Erinaceus europaeus","fullName":"Erinaceus europaeus (Western European hedgehog)"},"name":"Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein","description":["GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6) required for clathrin-dependent export of proteins from recycling endosomes to trans-Golgi network and cell surface. Required for regulated export of ITGB1 from recycling endosomes to the cell surface and ITGB1-dependent cell migration","GTPase-activating protein for the ADP ribosylation factor family"],"length":740,"sequence":"MTVKLDFEECLKDSPRFRASIELVEAEVSELETRLEKLLKLGTGLLDSGRHYVAAGRAFITGICDLARLGPPEPMMAECLDKFSESLNHKLDSHSELLDATQHTLQQQIQTLVKEGLRGFREARRDFWRGAESLEAALTHNAEVPRRRIQEAEEAGAALKTARAGYRGRALDYALQINVIEDKRKFDIMEFVLRLVEAQATHFQQGHEELNRLAQYRKELGAQLHQLVLNSAREKRDMEQRHVLLKQKELGGEEPEPSLREGPGGLVMEGHLFKRASNAFKTWSRRWFTIQSNQLVYQKKYKDPVTVVVDDLRLCTVKLCPDSDRRFCFEVVSPSKSCLLQADSERLLQLWISAVQSSIATAFSQAHLDDSPRGPGQGSGHLAVGSAATLGYSGMARGREPGGGGHVAAQVQSVDGNAQCCDCREPAPEWASINLGVTLCIQCSGIHRSLGVHFSKVRSLTLDSWEPELVKLMCELGNVVINQIYEARVEGMAVKKPGPSCSRQEKEAWIHAKYVEKKFLTKLPEIRGRRGGRGPPRGHPPVPPKPSVRLWPGSLKSKPESPSDDLGSLHPGALLFRAAGQPPCLPTMADALAHGADVNWVNGEQENATPLIQATAANSLLACEFLLQNGANVNQADNHGRGPLHHATILGHTGLACLFLKRGADLGALDSEGRDPLTIAMETANADIVTLLRLAKMREAEVALGQAGDETYLDIFRDFSLMASDAPEKLSRRSQDLHTL","proteome":"UP001652624","gene":"ACAP1","go_terms":[{"identifier":"GO:0005515","name":"protein binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0005737","name":"cytoplasm","category":{"code":"C","name":"cellular_component"}},{"identifier":"GO:0005096","name":"GTPase activator activity","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":4,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"09c67d4ad963853f9bf4e773ddc398d162b76d4e","counters":{"domain_architectures":7550,"entries":34,"isoforms":0,"proteomes":1,"sets":6,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":4,"ssf":4,"pfam":4,"cdd":3,"profile":4,"smart":3,"panther":1,"prints":1,"interpro":10},"proteome":1,"taxonomy":1,"similar_proteins":7550}}}