{"metadata":{"accession":"A0A1L9MZ75","id":"A0A1L9MZ75_ASPTC","source_organism":{"taxId":"767770","scientificName":"Aspergillus tubingensis (strain CBS 134.48)","fullName":"Aspergillus tubingensis (strain CBS 134.48)"},"name":"EKC/KEOPS complex subunit CGI121","description":["Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. CGI121 acts as an allosteric effector that regulates the t(6)A activity of the complex. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators. CGI121 is not required for tRNA modification"],"length":199,"sequence":"MSAPLLETIHLSHLPLSMPVHVALYRDVQNAPYLRQQLMSANAEFEYAFIDASTVLSRTHLLSAVFRAVNDYMNGRLKSRNVHSEMVFSLSPATNIAESFRKFGITDSTKDLLVVKLSVTPEITHDSVAAHLGQNVEGTPVPFDDETLSKISDIAKIKKAYKLGALNTTPPNQANGTQDNGMRRLELSVLGAIALRGAT","proteome":"UP000184304","gene":"ASPTUDRAFT_45604","go_terms":null,"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"fd915e41acd5042efaf0afef90965b3303da1187","counters":{"domain_architectures":4696,"entries":6,"isoforms":0,"proteomes":1,"sets":0,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":1,"ssf":1,"pfam":1,"panther":1,"interpro":2},"proteome":1,"taxonomy":1,"similar_proteins":4696}}}