{"metadata":{"accession":"A0A1L8G5S0","id":"A0A1L8G5S0_XENLA","source_organism":{"taxId":"8355","scientificName":"Xenopus laevis","fullName":"Xenopus laevis (African clawed frog)"},"name":"Squalene synthase","description":["Catalyzes the condensation of 2 farnesyl pyrophosphate (FPP) moieties to form squalene. Proceeds in two distinct steps. In the first half-reaction, two molecules of FPP react to form the stable presqualene diphosphate intermediate (PSQPP), with concomitant release of a proton and a molecule of inorganic diphosphate. In the second half-reaction, PSQPP undergoes heterolysis, isomerization, and reduction with NADPH or NADH to form squalene. It is the first committed enzyme of the sterol biosynthesis pathway"],"length":452,"sequence":"MASVNCKTAVSLFKRTLSLGPAQKPCGQRSLLTASRLQDRGLKEGRTVQICFAPQSQAVCRVHPVYFLQQDSMSDSLQTCYRYLNETSRSFAAVIQALDGELRHAVCIFYLVLRALDTVEDDMTIALETKTPMLHDFHTYLYQADWRYMDSKEKDKQVLEDFPTISLEFRKLAVIYQEVIADICHKMGVGMAEYLEKKVQTLQEWDQYCHYVAGLVGIGLSRLFSASELEDPIVGLDTQLSNSMGLFLQKTNIIRDYLEDQTEGREFWPKEVWGKYGKKLSDLANPEKIIPAVHCMNELITNALHHVPDVLTYLSRLKNQSVFNFCAIPQVMAIATLAACYNNQQVYKGVVKIRKGQAVTLMMDATNIEAVRAIMYQYVEEIYQKIPLTDPSSGRTQHIIASVRNLSLSDGSLASRNHFSPIYLSCAMLLAAISWQYLSTVSQVSEEVHSRQ","proteome":"UP000186698","gene":"fdft1.S","go_terms":[{"identifier":"GO:0051996","name":"squalene synthase [NAD(P)H] activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0009058","name":"biosynthetic process","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0045338","name":"farnesyl diphosphate metabolic process","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0008610","name":"lipid biosynthetic process","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0016765","name":"transferase activity, transferring alkyl or aryl (other than methyl) groups","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"7ee50707bedad879bc606a96fc69cbee4c35c950","counters":{"domain_architectures":33932,"entries":16,"isoforms":0,"proteomes":1,"sets":2,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":1,"ssf":1,"cdd":1,"pfam":1,"panther":1,"sfld":2,"ncbifam":1,"prosite":2,"interpro":6},"proteome":1,"taxonomy":1,"similar_proteins":33932}}}