{"metadata":{"accession":"A0A1F7RHM3","id":"A0A1F7RHM3_9BACT","source_organism":{"taxId":"1817876","scientificName":"Candidatus Schekmanbacteria bacterium GWA2_38_11","fullName":"Candidatus Schekmanbacteria bacterium GWA2_38_11"},"name":"Multifunctional fusion protein","description":["Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis","Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions"],"length":346,"sequence":"MKPVKKIGVLTGGGDCPGLNAAIRAVVRRANSYGYEVIGIKRGWHGLIYGETEPLTNFSVSGILHVGGTIIGTSRTNPFKNEEDLQRLLANYKKFGIDALISIGGEDTLGVAYKLSEKGIPIVGIPKTIDNDLSGTDFTFGFDTAVTIVTDAIDRLHSTAESHDRIMVVEVMGRHTGWIATFGGIAGGADIILIPEVSFDIGEVCTMIKKRHERGKNFSIIVVAEGAKPKDVDKYITSSNQVDEFGHIKLGGVGNFLGTEIEKRTGYDTRVTVLGHIQRGGSPTANDRVLATRFGVAAVDLIKEGKFGRMVALQCNKIVDIDISEPVKKLKTVDPDLYEIAKVFFG","proteome":null,"gene":"pfkA","go_terms":[{"identifier":"GO:0003872","name":"6-phosphofructokinase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006096","name":"glycolytic process","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0005524","name":"ATP binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0008443","name":"phosphofructokinase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006002","name":"fructose 6-phosphate metabolic process","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0047334","name":"diphosphate-fructose-6-phosphate 1-phosphotransferase activity","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"c47239981a029609f58ab64a8107d57cef15dd9e","counters":{"domain_architectures":37322,"entries":19,"isoforms":0,"proteomes":0,"sets":1,"structures":0,"taxa":1,"dbEntries":{"ssf":1,"pfam":1,"cathgene3d":2,"panther":1,"pirsf":1,"hamap":2,"ncbifam":2,"prosite":1,"prints":1,"interpro":7},"proteome":0,"taxonomy":1,"similar_proteins":37322}}}