{"metadata":{"accession":"A0A1A6HFF6","id":"A0A1A6HFF6_NEOLE","source_organism":{"taxId":"56216","scientificName":"Neotoma lepida","fullName":"Neotoma lepida (Desert woodrat)"},"name":"FAS-associated death domain protein","description":["Apoptotic adapter molecule that recruits caspases CASP8 or CASP10 to the activated FAS/CD95 or TNFRSF1A/TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs CASP8 proteolytic activation. Active CASP8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling"],"length":208,"sequence":"MDPFLVLLHSLSGSLSNSDLMELKFLCRERVGKRKLERVQSGLDLFSVLLEQNDLERGRTGLLRELLASLRRHDLLQRLDDFEAGTAASAAPGEADLRVAFDIVCDNLGRDWKRLARQLKLSEAKIDGIEERYPRSLSDQVRETLRVWKIAEREKATAAGLVKALRACRLNLVADLVEEALQAQGSVNESDDVSPVLWDPTVSSSEAL","proteome":"UP000092124","gene":"A6R68_16248","go_terms":[{"identifier":"GO:0005515","name":"protein binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0042981","name":"regulation of apoptotic process","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0007165","name":"signal transduction","category":{"code":"P","name":"biological_process"}}],"protein_evidence":4,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"f9d417453a13a610dfd4db30c29f560ffa4ad87e","counters":{"domain_architectures":861,"entries":17,"isoforms":0,"proteomes":1,"sets":2,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":1,"ssf":1,"smart":2,"profile":2,"pfam":2,"cdd":2,"pirsf":1,"panther":1,"interpro":5},"proteome":1,"taxonomy":1,"similar_proteins":861}}}