{"metadata":{"accession":"A0A151ND70","id":"A0A151ND70_ALLMI","source_organism":{"taxId":"8496","scientificName":"Alligator mississippiensis","fullName":"Alligator mississippiensis (American alligator)"},"name":"Ran-binding protein 3","description":["Acts as a cofactor for XPO1/CRM1-mediated nuclear export, perhaps as export complex scaffolding protein. Bound to XPO1/CRM1, stabilizes the XPO1/CRM1-cargo interaction. In the absence of Ran-bound GTP prevents binding of XPO1/CRM1 to the nuclear pore complex. Binds to CHC1/RCC1 and increases the guanine nucleotide exchange activity of CHC1/RCC1. Recruits XPO1/CRM1 to CHC1/RCC1 in a Ran-dependent manner. Negative regulator of TGF-beta signaling through interaction with the R-SMAD proteins, SMAD2 and SMAD3, and mediating their nuclear export"],"length":521,"sequence":"MADLANEEKPAIAPPVFVFQKDKAQKRSADGSSPEDGEDSDHEDGSYCPPVKRERTSSLTQFPPSQSVTKNNVFMPSSFCEPSTGNSDSEPEEKSSGFRLKPPTLIHGQAPSAGLPSQKPKEQQRSVLRPAVLQAPQPKAFSQMVPSSGTNGINAPPDSGVAAPSESLISTTVKRSDSEDKARECQKKELNSTTEDDNYEKPEQNAQQAFVFGQNLRDRVKLGDESDETVEVQIAGLPSSDPPSATNYFLQYISSSLENSTNSADPSSNKFVFGQNMSERVLSPPKSNDGGTESNKENTASESGSESSSQEATPEKANNISESLAESAAAYTKATARKCLLEKVEVITGEEAESNVLQIQCKLFVFDKNSQSWVERGRGLLRLNDMASTDDGTLQSRLVMRTQGSLRLILNTKLWAQMQIDKASEKSIRITAMDTEDQGVKVFLISASSKDTGQLYAALHHRILALRSRVEQEQEAKSTAPEPEVSQSNEEDSDDDDVITPSGSAGSGPNDEGDGQNVGST","proteome":"UP000050525","gene":"RANBP3","go_terms":[{"identifier":"GO:0046907","name":"intracellular transport","category":{"code":"P","name":"biological_process"}}],"protein_evidence":4,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"4b4402e44ce7d470ca74eb6ce94573d79fb78383","counters":{"domain_architectures":12060,"entries":10,"isoforms":0,"proteomes":1,"sets":2,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":1,"smart":1,"ssf":1,"profile":1,"pfam":1,"cdd":1,"panther":1,"interpro":3},"proteome":1,"taxonomy":1,"similar_proteins":12060}}}