{"metadata":{"accession":"A0A151MEB7","id":"A0A151MEB7_ALLMI","source_organism":{"taxId":"8496","scientificName":"Alligator mississippiensis","fullName":"Alligator mississippiensis (American alligator)"},"name":"Methyltransferase HEMK2","description":["Methyltransferase that can methylate proteins and, to a lower extent, arsenic. Catalytic subunit of a heterodimer with TRMT112, which monomethylates 'Lys-12' of histone H4 (H4K12me1), a modification present at the promoters of numerous genes encoding cell cycle regulators. Catalytic subunit of a heterodimer with TRMT112, which catalyzes N5-methylation of Glu residue of proteins with a Gly-Gln-Xaa-Xaa-Xaa-Arg motif. Methylates ETF1 on 'Gln-185'; ETF1 needs to be complexed to ERF3 in its GTP-bound form to be efficiently methylated. May also play a role in the modulation of arsenic-induced toxicity by mediating the conversion of monomethylarsonous acid (3+) into the less toxic dimethylarsonic acid. It however only plays a limited role in arsenic metabolism compared with AS3MT"],"length":217,"sequence":"MAAPALPTPQHHHVGPRGPFCEVYEPAEDTYLLLDALELDAAQLRNARVEICLEVGSGSGVVSTFLASIVGPKALYICTDINPTAAFCTMETALLNKVHIQPIITDLVTGLVPRLNGQVDVLLFNPPYVVTPPEEAESHGIEAAWAGGKNGREVMDRLFPLVADLLSTGGLFYLVTIKENNPDEILEIMKQCGLRGAKVLSRRAGKEMLTILKFSKS","proteome":"UP000050525","gene":"N6AMT1","go_terms":[{"identifier":"GO:0008168","name":"methyltransferase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0003676","name":"nucleic acid binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0032259","name":"methylation","category":{"code":"P","name":"biological_process"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"0d8b878601c6bceffbd1ea258abe6a468799d091","counters":{"domain_architectures":46530,"entries":12,"isoforms":0,"proteomes":1,"sets":2,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":1,"ssf":1,"pfam":1,"cdd":1,"panther":1,"ncbifam":1,"prosite":1,"interpro":5},"proteome":1,"taxonomy":1,"similar_proteins":46530}}}