{"metadata":{"accession":"A0A0N8EUF1","id":"A0A0N8EUF1_HETGA","source_organism":{"taxId":"10181","scientificName":"Heterocephalus glaber","fullName":"Heterocephalus glaber (Naked mole rat)"},"name":"rRNA methyltransferase 2, mitochondrial","description":["S-adenosyl-L-methionine-dependent 2'-O-ribose methyltransferase that catalyzes the formation of 2'-O-methyluridine at position 1369 (Um1369) in the 16S mitochondrial large subunit ribosomal RNA (mtLSU rRNA), a universally conserved modification in the peptidyl transferase domain of the mtLSU rRNA. This activity may require prior 2'-O-methylguanosine modification at position 1370 (Gm1370) by MRM3. Essential for late-stage assembly of mtLSU required for efficient translation of mitochondrial DNA encoded proteins; methyltransferase activity is not required for this function. Essential for mitochondrial respiratory function"],"length":246,"sequence":"MAGYWKLVCASLFCERFHTAAQHYKGRTGAEHLWLMRHLKDPYVKAAKVECYRCRSAFKLLEMNEKHGILRPGLRVLDCGAAPGAWSQVAVQRVNATGADPSFPVGFVLGVDLLHIHPLEGATFLSPADVTDPRTFQRIMELLPCGKADVILSDMAPNATGIRDLDHDRLISMCLSLLDMAPDILHPGGTVLCKTWAGSQSRRLQKRLTEEFQNTRTIKPEASRKESSEVYFLATQYRRRKGSVKQ","proteome":null,"gene":"FTSJ2","go_terms":[{"identifier":"GO:0008168","name":"methyltransferase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0001510","name":"RNA methylation","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0032259","name":"methylation","category":{"code":"P","name":"biological_process"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"71a5d42e748b06cd2d42035318a449fe592a7c1a","counters":{"domain_architectures":26600,"entries":10,"isoforms":0,"proteomes":0,"sets":1,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":1,"ssf":1,"pirsf":1,"panther":1,"hamap":1,"pfam":1,"interpro":4},"proteome":0,"taxonomy":1,"similar_proteins":26600}}}