{"metadata":{"accession":"A0A0G4G249","id":"A0A0G4G249_9ALVE","source_organism":{"taxId":"1169474","scientificName":"Chromera velia CCMP2878","fullName":"Chromera velia CCMP2878"},"name":"Oxidized purine nucleoside triphosphate hydrolase","description":["Oxidized purine nucleoside triphosphate hydrolase which is a prominent sanitizer of the oxidized nucleotide pool. Catalyzes the hydrolysis of 2-oxo-dATP (2-hydroxy-dATP) into 2-oxo-dAMP. Also has a significant hydrolase activity toward 2-oxo-ATP, 8-oxo-dGTP and 8-oxo-dATP. Through the hydrolysis of oxidized purine nucleoside triphosphates, prevents their incorporation into DNA and the subsequent transversions A:T to C:G and G:C to T:A. Also catalyzes the hydrolysis of methylated purine nucleoside triphosphate preventing their integration into DNA. Through this antimutagenic activity protects cells from oxidative stress"],"length":365,"sequence":"MFKSVAVRTFSLCAVLEAAAQVRPRKLYSVVFVYNEDKTEMLMGYKKIGFGQGKYNGFGGKKEDWETTTECAYRELAEESGLIAHNMKLEGLLRSTREEPDSLLMDVYMFSTDRWEGTITESDEMAPVWFPVSEIPFHSMWPDNKEWFNLILEDERFIASFVYNDRDEVVAGDVRVVSDEEISETLRRDDAIGNVHSGSTVEAPSLTQPAPVRQGASVSSDHPISEHTGEQEEEQLPVAVYEWGQATDASPARMETAQSAERGDEDREGGASALTALVHEMAVQHHQEASSSAPSVEEEDEEVRSLSSLRAGASGGTRGGASRSKRWLGNGRLASQLQTLAAWPFRWFRKGAAEAEPGTATVARG","proteome":null,"gene":"Cvel_19892","go_terms":[{"identifier":"GO:0008413","name":"8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0042262","name":"DNA protection","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0016787","name":"hydrolase activity","category":{"code":"F","name":"molecular_function"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"752b3b6d9807717ea1f029db1420a2538cb188ca","counters":{"domain_architectures":250306,"entries":12,"isoforms":0,"proteomes":0,"sets":2,"structures":0,"taxa":1,"dbEntries":{"profile":1,"cathgene3d":1,"cdd":1,"ssf":1,"pfam":1,"panther":1,"prints":1,"prosite":1,"interpro":4},"proteome":0,"taxonomy":1,"similar_proteins":250306}}}