{"metadata":{"accession":"A0A091X4J6","id":"A0A091X4J6_OPIHO","source_organism":{"taxId":"30419","scientificName":"Opisthocomus hoazin","fullName":"Opisthocomus hoazin (Hoatzin)"},"name":"NADPH oxidase 4","description":["NADPH oxidase that catalyzes predominantly the reduction of oxygen to H2O2. Can also catalyze to a smaller extent, the reduction of oxygen to superoxide. May function as an oxygen sensor regulating the KCNK3/TASK-1 potassium channel and HIF1A activity. May regulate insulin signaling cascade. May play a role in apoptosis, bone resorption and lipolysaccharide-mediated activation of NFKB. May produce superoxide in the nucleus and play a role in regulating gene expression upon cell stimulation. Promotes ferroptosis, reactive oxygen species production and reduced glutathione (GSH) levels by activating NLRP3 inflammasome activation and cytokine release"],"length":531,"sequence":"LGLCVSRASASVLNLNCCLVLLPMCRVLLAFLRGSRKVASRKTRRLLDKSKTFHVTCGVTICIFSVLHVAAHLVNALNFSENYNEDFLSINAANYRGEDPRKLLFASVPGLTGVIMVLVLFLMCTGSTYAIRVSNYDIFWYTHNLFFVFYMLLMLHVSGGVLKYQTNLEEHPPGCFNPNKTLRENMTVPKAFEELFPDYTTGPFPEDLSVPEPFVQNNFMRICSEEPKFQSHFPETWFWISGPLCLYCVERLYRYIRSSKPVTITSVISHPSNVLEVRMMKDDFKARPGQYVILNCPRVSALESHPFTLTMCPTDTKATFGVHLKVVGDWTERFRDLLLLHSNQDAEILPIFQQRRYPKLYVDGPFGSPFEESLNYEVSLCVAGGIGVTPFASVLNTLLDGWKCYKLRRLYFIWVCRDIESFRWFADLLCMLHNKLWQENRPDYINIQLYLSQTDGIQKIIGEKYQALNSRLLTGRPRWKLLFDEIAKCNRRKTIGVFCCGPNKLSKILHKLSNSSNSYGTRFEYNKESFS","proteome":"UP000053605","gene":"N306_00094","go_terms":[{"identifier":"GO:0016491","name":"oxidoreductase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0016020","name":"membrane","category":{"code":"C","name":"cellular_component"}}],"protein_evidence":4,"source_database":"unreviewed","is_fragment":true,"in_alphafold":true,"in_bfvd":false,"ida_accession":"496ce31aafc2f777618f119f81f7277d9a382e44","counters":{"domain_architectures":22735,"entries":19,"isoforms":0,"proteomes":1,"sets":4,"structures":0,"taxa":1,"dbEntries":{"pfam":3,"cathgene3d":2,"profile":1,"ssf":2,"cdd":1,"panther":1,"prints":1,"interpro":8},"proteome":1,"taxonomy":1,"similar_proteins":22735}}}