{"metadata":{"accession":"A0A091RY44","id":"A0A091RY44_NESNO","source_organism":{"taxId":"176057","scientificName":"Nestor notabilis","fullName":"Nestor notabilis (Kea)"},"name":"Presenilin","description":["Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. May function in the cytoplasmic partitioning of proteins. The holoprotein functions as a calcium-leak channel that allows the passive movement of calcium from endoplasmic reticulum to cytosol and is involved in calcium homeostasis. Is a regulator of mitochondrion-endoplasmic reticulum membrane tethering and modulates calcium ions shuttling between ER and mitochondria","Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors"],"length":458,"sequence":"MITFMNNSDSEEEPCNERTSLMSAESPPVPSYQDGLQASGAGEAQAHRKRRTGSSRSPNNIAEGEMSDSGVPVRGSALENEEEELTLKYGAKHVIMLFVPVTLCMIVVVATIKSVRFYTEKNGQLIYTPFSEDTPSVGQRLLNSVLNTIIMISVIVVMTVFLVLLYKYRCYKFIHGWLILSSLMLLFLFTYIYLGEVLKTYNVAMDYPTLFLVIWNFGAVGMICIHWKGPLQLQQAYLIMISALMALVFIKYLPEWSAWVILGAISIYDLMAVLCPKGPLRMLVETAQERNEPIFPALIYSSAMMWTVGMAKPDTAARGPSQQMWDAAEDGRDNHGSSSHTDSQMSETRSPVPTRPITSLEELEEEERGVKLGLGDFIFYSVLVGKAAATASGDWNTTLACFVAILIGLCLTLLLLAVFKKALPALPISITFGLVFYFSTDNLVRPFMDTLASHQLYI","proteome":"UP000053840","gene":"N333_10345","go_terms":[{"identifier":"GO:0042500","name":"aspartic endopeptidase activity, intramembrane cleaving","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0016020","name":"membrane","category":{"code":"C","name":"cellular_component"}},{"identifier":"GO:0016485","name":"protein processing","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0035556","name":"intracellular signal transduction","category":{"code":"P","name":"biological_process"}},{"identifier":"GO:0042987","name":"amyloid precursor protein catabolic process","category":{"code":"P","name":"biological_process"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"c661181a01b211ed2d1c8b8b5e8a3bdf1b271f93","counters":{"domain_architectures":4227,"entries":10,"isoforms":0,"proteomes":1,"sets":1,"structures":0,"taxa":1,"dbEntries":{"smart":1,"cathgene3d":1,"panther":1,"pfam":1,"prints":2,"interpro":4},"proteome":1,"taxonomy":1,"similar_proteins":4227}}}