{"metadata":{"accession":"A0A091JE86","id":"A0A091JE86_EGRGA","source_organism":{"taxId":"188379","scientificName":"Egretta garzetta","fullName":"Egretta garzetta (Little egret)"},"name":"NADPH oxidase 2","description":["Catalytic subunit of the phagocyte NADPH oxidase complex that mediates the transfer of electrons from cytosolic NADPH to O2 to produce the superoxide anion (O2(-)). In the activated complex, electrons are first transferred from NADPH to flavin adenine dinucleotide (FAD) and subsequently transferred via two heme molecules to molecular oxygen, producing superoxide through an outer-sphere reaction. Activation of the NADPH oxidase complex is initiated by the assembly of cytosolic subunits of the NADPH oxidase complex with the core NADPH oxidase complex to form a complex at the plasma membrane or phagosomal membrane. This activation process is initiated by phosphorylation dependent binding of the cytosolic NCF1/p47-phox subunit to the C-terminus of CYBA/p22-phox. NADPH oxidase complex assembly is impaired through interaction with NRROS"],"length":570,"sequence":"MGNWVENEGLSIFVVLVWLGLNVFLFWWYYLVYDVPPKFFYTRVLLGRALALARAPAACLNFNCMLILLPVCRNLLSFLRGSSACCSTRVRRQLDRNLTFHKMVAWMIALHTAIHTIAHLFNVEWNVQARVEETRTLAAALSSLGDDPKQSYVNFYRNTIANPVGGLYVAFTYLAGLTGVIITLALILIITSSTKTIRRSYFEVFWYTHHLFVIFFIGLVIHGAGRIVRGQTAESLAEHNPEICYKNFSSWGSKGSCPIPQFSGNPPMTWKWVVGPMFLYLCERLVRLWRSQQKVVITKVVIHPFKTIELQMMKKGFKMEVGQYIFVKCPAVSKLEWHPFTLTSAPEEDYFSIHVRIVGDWTEGLFNACGCDKQEFQEAWKLPKIAVDGPFGTASEDVFSYETVMLVGAGIGVTPFASVLKSVWYKYCHDATNLKLKKIYFYWLCRDTHAFEWFADLLQSLEAQMQERNNADFLSYNIYLTGWDESQATHFVVHHEEEKDVITGLKQKTLYGRPNWENEFKTIAGKHPGSRIGVFLCGPEGLADTLNKQSISNSEADPRGVHFIFNKENF","proteome":"UP000053119","gene":"Z169_14677","go_terms":[{"identifier":"GO:0016491","name":"oxidoreductase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0016020","name":"membrane","category":{"code":"C","name":"cellular_component"}}],"protein_evidence":4,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"496ce31aafc2f777618f119f81f7277d9a382e44","counters":{"domain_architectures":22735,"entries":21,"isoforms":0,"proteomes":1,"sets":4,"structures":0,"taxa":1,"dbEntries":{"pfam":3,"profile":1,"cathgene3d":2,"ssf":2,"cdd":1,"panther":1,"sfld":2,"prints":1,"interpro":8},"proteome":1,"taxonomy":1,"similar_proteins":22735}}}