{"metadata":{"accession":"A0A091IIC6","id":"A0A091IIC6_CALAN","source_organism":{"taxId":"9244","scientificName":"Calypte anna","fullName":"Calypte anna (Anna's hummingbird)"},"name":"Dual specificity mitogen-activated protein kinase kinase 5","description":["Acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appears to play a critical role in protecting cells from stress-induced apoptosis, neuronal survival and cardiac development and angiogenesis. As part of the MAPK/ERK signaling pathway, acts as a negative regulator of apoptosis in cardiomyocytes via promotion of STUB1/CHIP-mediated ubiquitination and degradation of ICER-type isoforms of CREM"],"length":438,"sequence":"SRAMESQALVIRIRIPDGGAVDWTVHSAPQLLFRDVLDVIGQVLPDATTTAFEYEDEDGDRITVRSDEEMKAMLSYYYSTVMEQQVNGQLIEPLQIYPRACKPPGKRNIHGLKVNTRAGAANNSSSAVSDSLPSNSLKKSSAELKKILANGQMNEQDIRYRDILGHGNGGTVYKAYHVPSGKILAVKVIPLDITLELQKQIMSELEILYKCDSSYIIGFYGAFFVENRISLCTEFMDGGSLDVYRKIPEHVLGRIAVAVVKGLTYLWSLKILHRDVKPSNMLVNTRGQVKLCDFGVSTQLVNSIAKTYVGTNAYMAPERISGEQYGIHSDVWSLGISFMELALGRFPYPQIQKNQGSLMPLQLLQCIVDEESPVLPAGEFSEPFVHFITQCMKKQPKERPAPEDLMGHPFIVQYNDGNAEVVSMWVCRMLEERRSTQG","proteome":"UP000054308","gene":"N300_05575","go_terms":[{"identifier":"GO:0005515","name":"protein binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0004672","name":"protein kinase activity","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0005524","name":"ATP binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0006468","name":"protein phosphorylation","category":{"code":"P","name":"biological_process"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":true,"in_alphafold":true,"in_bfvd":false,"ida_accession":"7a179ec1a11ca99520405944c9c43a044671b035","counters":{"domain_architectures":3895,"entries":24,"isoforms":0,"proteomes":1,"sets":4,"structures":0,"taxa":1,"dbEntries":{"ssf":2,"cathgene3d":3,"cdd":2,"smart":2,"profile":2,"pfam":2,"panther":1,"prosite":2,"interpro":8},"proteome":1,"taxonomy":1,"similar_proteins":3895}}}