{"metadata":{"accession":"A0A091DTM3","id":"A0A091DTM3_FUKDA","source_organism":{"taxId":"885580","scientificName":"Fukomys damarensis","fullName":"Fukomys damarensis (Damaraland mole rat)"},"name":"Protein NNX3","description":["Plays a central role in maintaining S6K1 signaling and BAD phosphorylation under normal growth conditions thereby protecting cells from potential deleterious effects of sustained S6K1 signaling. The URI1-PPP1CC complex acts as a central component of a negative feedback mechanism that counteracts excessive S6K1 survival signaling to BAD in response to growth factors. Mediates inhibition of PPP1CC phosphatase activity in mitochondria. Coordinates the regulation of nutrient-sensitive gene expression availability in a mTOR-dependent manner. Seems to be a scaffolding protein able to assemble a prefoldin-like complex that contains PFDs and proteins with roles in transcription and ubiquitination"],"length":493,"sequence":"MEANFMIFLGKKVDDDYNALQERLSTLPDKLSYNIMVPFGPFAFMPGKLVHTNEVTVLLGDNWFAKCSAKQAVGLVEHRKEHIRKTIDDLKKVMKNFESRVEFTEDLQKMSDVGDIVDIREEIKSDFEFKGKQRIAHKPHSKPKTSGIFEADFVSDVKSKDFLADKELWARLEELERQEELLGELDSKPDTVITNGEDTTSSEEEREDQNTNMNVMQPVTDSLAPSACPKGVVNSELFRGHVNSKLNCSGNGSDSYRSDEDDDEEEDDDGGSDNENDHDASGAADNSVPTIYFSHTVEPKRVRINTGKNTTLKFSEKKEEAKRKRKNSSGSGQSAHELPTIRTPADIYRVFVDVVNGEYVPRKSILKSRSRENSVCSDTSESSATEFDERRGVLRSISCEEATCSDTSGSILEEEPQEENPQKKLLPSLGAPEAFSGTVIEKEFLSSSLTPHPAIAHPVLPTIPERKEILSEAAEETAKRVSKFKAARLQQKS","proteome":"UP000028990","gene":"H920_12482","go_terms":null,"protein_evidence":3,"source_database":"unreviewed","is_fragment":false,"in_alphafold":true,"in_bfvd":false,"ida_accession":"bc0bdc5e1accc6ba61a70135255c8cbcb5257e7e","counters":{"domain_architectures":14091,"entries":8,"isoforms":0,"proteomes":1,"sets":1,"structures":0,"taxa":1,"dbEntries":{"cdd":1,"cathgene3d":1,"ssf":1,"panther":1,"pfam":1,"interpro":3},"proteome":1,"taxonomy":1,"similar_proteins":14091}}}