{"metadata":{"accession":"A0A087VHD1","id":"A0A087VHD1_BALRE","source_organism":{"taxId":"100784","scientificName":"Balearica regulorum gibbericeps","fullName":"Balearica regulorum gibbericeps (East African grey crowned-crane)"},"name":"Ankyrin repeat and SOCS box protein 8","description":["May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits IFN-beta production through the IRF3 signaling pathway by targeting TBK1 via 'Lys-48'-linked ubiquitination, leading to its proteasomal degradation"],"length":249,"sequence":"VLSQGADVNCMHGTLKPLHCACMVADADCVELLLQKGAEVNALDGYNRTALHYAAEKDETCVEILLEYGANPNALDGNKDTPLHWAAFKNNAECVRSLLENGALVNARDYNNDTPLSWAAMKGNLESVSILLDFGAEVRVVNLKGQTPISRLVALLVRGLGTEREDSCFDLLHRAIGHFELRKNGSMPWEVTRDPQLCEKLTLLCSVPGTLQTLSRYAVRRSLGVRFLPEAVKQLPLPTCLKEYVLLLS","proteome":"UP000053309","gene":"N312_07552","go_terms":[{"identifier":"GO:0005515","name":"protein binding","category":{"code":"F","name":"molecular_function"}},{"identifier":"GO:0035556","name":"intracellular signal transduction","category":{"code":"P","name":"biological_process"}}],"protein_evidence":3,"source_database":"unreviewed","is_fragment":true,"in_alphafold":true,"in_bfvd":false,"ida_accession":"7c2d8187b84953095ba3d60b03f38bc17a6a12e6","counters":{"domain_architectures":269,"entries":19,"isoforms":0,"proteomes":1,"sets":3,"structures":0,"taxa":1,"dbEntries":{"cathgene3d":2,"ssf":2,"smart":2,"profile":3,"pfam":3,"cdd":1,"panther":1,"interpro":5},"proteome":1,"taxonomy":1,"similar_proteins":269}}}