"accession"	"counters"	"cross_references"	"description"	"entry_id"	"go_terms"	"hierarchy"	"integrated"	"is_llm"	"is_reviewed_llm"	"is_updated_llm"	"literature"	"member_databases"	"name"	"overlaps_with"	"representative_structure"	"set_info"	"source_database"	"type"	"wikipedia"
"PS51253"	"{'subfamilies': 0, 'domain_architectures': 0, 'interactions': 0, 'matches': 30844, 'pathways': 0, 'proteins': 30463, 'proteomes': 2562, 'sets': 0, 'structural_models': {'alphafold': 25959, 'bfvd': 0}, 'structures': 2, 'taxa': 7471}"	"{}"	"[{'text': '<p>The CENPB-type HTH domain is a DNA-binding, helix-turn-helix (HTH) domain of\nabout 70-75 amino acids, present in eukaryotic centromere proteins and\ntransposases. The domain is named after the mammalian major centromere\nautoantigen B or centromere protein B (CENP-B), which is a fundamental\ncentromere component of chromosomes. The N-terminus of CENP-B contains two\nDNA-binding HTH domains, which bind to adjacent major grooves of DNA. The\nN-terminus of CENP-B is formed by a psq-type HTH domain and\nC-terminal to this domain lies the CENPB-type HTH domain. These two HTH\ndomains together bind specifically to a 17-base-pair sequence, the CENP-B box,\nwhich occurs in alpha-satellite DNA in human centromeres [[cite:PUB00035346]].\n\nThe structure of the CENPB-type HTH domain is composed of three alpha-helices. The second and third helices connected via a turn comprise\nthe helix-turn-helix motif. Helix 3 is termed the recognition helix as it\nbinds the DNA major groove, like in other HTHs. In CENP-B this domain\nrecognizes site 3 of the CENP-B box, while the preceding psq-type HTH binds site 1 of the CENP-B box, and a connecting linker loop\nbinds in the minor groove of DNA and recognizes site 2 [[cite:PUB00025705]].\n\nSome proteins known to contain a CENPB-type HTH domain:\n\n - Mammalian centromere protein B (CENP-B), associated with the centromere and\n   specifically binding DNA to the CENP-B box.\n - Mammalian jerky protein, involved in epileptic seizures in mice.\n - Mammalian Pogo transposases.\n - Fission  yeast  ARS-binding  protein  1  (abp1) and CENP-B homolog proteins\n   (CBHP-1 and 2), which are centromere proteins.\n - Candida albicans protein PDC2.\n - Fungal transposases.\n\nThe profile we developed covers the entire CENPB-type HTH domain, including\nthe N-terminal linker loop.</p>', 'llm': False, 'checked': False, 'updated': False}]"	""	""	""	"IPR006600"	False	False	False	"{'PUB00035346': {'PMID': 16183641, 'ISBN': None, 'volume': '280', 'issue': '50', 'year': 2005, 'title': 'Human centromere protein B induces translational positioning of nucleosomes on alpha-satellite sequences.', 'URL': None, 'raw_pages': '41609-18', 'medline_journal': 'J Biol Chem', 'ISO_journal': 'J. Biol. Chem.', 'authors': ['Tanaka Y', 'Tachiwana H', 'Yoda K', 'Masumoto H', 'Okazaki T', 'Kurumizaka H', 'Yokoyama S.'], 'DOI_URL': 'http://dx.doi.org/10.1074/jbc.M509666200'}, 'PUB00025705': {'PMID': 11726497, 'ISBN': None, 'volume': '20', 'issue': '23', 'year': 2001, 'title': 'Crystal structure of the CENP-B protein-DNA complex: the DNA-binding domains of CENP-B induce kinks in the CENP-B box DNA.', 'URL': None, 'raw_pages': '6612-8', 'medline_journal': 'EMBO J', 'ISO_journal': 'EMBO J.', 'authors': ['Tanaka Y', 'Nureki O', 'Kurumizaka H', 'Fukai S', 'Kawaguchi S', 'Ikuta M', 'Iwahara J', 'Okazaki T', 'Yokoyama S.'], 'DOI_URL': 'http://dx.doi.org/10.1093/emboj/20.23.6612'}}"	""	"{'name': 'CENPB-type HTH domain profile', 'short': 'HTH_CENPB'}"	""	""	""	"profile"	"domain"	""