"accession"	"counters"	"cross_references"	"description"	"entry_id"	"go_terms"	"hierarchy"	"integrated"	"is_llm"	"is_reviewed_llm"	"is_updated_llm"	"literature"	"member_databases"	"name"	"overlaps_with"	"representative_structure"	"set_info"	"source_database"	"type"	"wikipedia"
"PR01920"	"{'subfamilies': 0, 'domain_architectures': 0, 'interactions': 0, 'matches': 1359, 'pathways': 0, 'proteins': 300, 'proteomes': 145, 'sets': 0, 'structural_models': {'alphafold': 269, 'bfvd': 0}, 'structures': 0, 'taxa': 470}"	"{}"	"[{'text': '<p>  The tumour necrosis factor (TNF) receptor (TNFR) superfamily comprises more than 20 type-I transmembrane proteins. Family members are defined based on similarity in their extracellular domain - a region that contains many cysteine residues arranged in a specific repetitive pattern [7917108]. The cysteines allow formation of an extended rod-like structure, responsible for ligand binding [8387891]. </p> <p> Upon receptor activation, different intracellular signalling complexes are assembled for different members of the TNFR superfamily, depending on their intracellular domains and sequences [15500863]. Activation of TNFRs can therefore induce a range of disparate effects, including cell proliferation, differentiation, survival, or apoptotic cell death, depending upon the receptor involved [11239407,9826575]. </p> <p> TNFRs are widely distributed and play important roles in many crucial biological processes, such as lymphoid and neuronal development, innate and adaptive immunity, and maintenance of cellular homeostasis [15500863]. Drugs that manipulate their signalling have potential roles in the prevention and treatment of many diseases, such as viral infections, coronary heart disease, transplant rejection, and immune disease [9826574]. </p> <p> TNF receptor 3 (also known as lymphotoxin-beta receptor) acts as a receptor for the heterotrimer of lymphotoxin-alpha and beta, and also for the TNF ligand LIGHT. Activation of the receptor promotes apoptosis via recruitment of TNFR-associated factor 3 (TRAF3) [9122217]. </p>', 'llm': False, 'checked': False, 'updated': False}]"	""	""	""	"IPR017349"	False	False	False	""	""	"{'name': 'Tumour necrosis factor receptor 3', 'short': 'TNFACTORR3'}"	""	""	""	"prints"	"family"	""