{"metadata":{"accession":"PF31256","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR061907","hierarchy":null,"name":{"name":"Domain of unknown function (DUF8846)","short":"DUF8846"},"description":[{"text":"<p>This entry represents a domain of unknown function found in uncharcaterised proteins from Alphaproteobacteria, predominantly in Rhodobacterales (including Roseobacteraceae and Paracoccaceae). The domain is approximately 100 residues in length and is predicted to adopt an alpha/beta structure containing a four stranded antiparallel beta-sheet. STRING analysis shows these proteins are consistently associated with cell division and secretion system proteins, including DivIB ([pfam:PF03799]), RodZ ([pfam:PF13464]) and SPOR domain proteins ([pfam:PF05036]). The specific function of this domain remains to be determined.</p>","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"<p>A <b>domain of unknown function</b> (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.</p>","thumbnail":null}],"literature":null,"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":1,"interactions":0,"matches":599,"pathways":0,"proteins":599,"proteomes":598,"sets":0,"structural_models":{"alphafold":451},"structures":0,"taxa":827},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":72,"alignment:full":423},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}