This entry represents a domain of unknown function frequently found C-terminal in proteins from Actinomycetota. This domain is distantly related to [pfam:PF19374] (DUF5949). The gene SCO1756 encoding a protein with this domain was found to be more abundant in bacterioferritin mutants during morphological differentiation [[cite:PUB00163738]], although the specific function of this domain remains to be determined.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00163738":{"PMID":39182107,"ISBN":null,"volume":"23","issue":"1","year":2024,"title":"Functional connexion of bacterioferritin in antibiotic production and morphological differentiation in Streptomyces coelicolor.","URL":null,"raw_pages":"234","medline_journal":"Microb Cell Fact","ISO_journal":"Microb Cell Fact","authors":["Garcia-Martin J","Garcia-Abad L","Santamaria RI","Diaz M."],"DOI_URL":"https://doi.org/10.1186/s12934-024-02510-1"}},"set_info":{"accession":"CL1009","name":"DUF5949-like"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":2,"interactions":0,"matches":837,"pathways":0,"proteins":837,"proteomes":826,"sets":1,"structural_models":{"alphafold":361},"structures":0,"taxa":888},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":78,"alignment:full":403},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}