{"metadata":{"accession":"PF31225","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR061902","hierarchy":null,"name":{"name":"Domain of unknown function (DUF8841)","short":"DUF8841"},"description":[{"text":"<p>This entry represents a domain found in probable transcriptional regulators from Actinomycetota predominantly in the genus Streptomyces. These proteins contain an N-terminal helix-turn-helix DNA-binding domain followed by this domain. The function of this domain is unknown.</p>","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"<p>A <b>domain of unknown function</b> (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.</p>","thumbnail":null}],"literature":null,"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":6,"interactions":0,"matches":725,"pathways":0,"proteins":724,"proteomes":562,"sets":0,"structural_models":{"alphafold":286},"structures":0,"taxa":645},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":98,"alignment:full":336},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}