This entry represents a membrane protein domain of approximately 70 residues found in Streptomyces and related Actinomycetes. In Streptomyces coelicolor, SCO4131 containing this domain is located in a gene cluster (SCO4126-SCO4131) that affects actinorhodin antibiotic biosynthesis [[cite:PUB00163737]]. The function of this domain remains to be determined.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00163737":{"PMID":28062460,"ISBN":null,"volume":"83","issue":"6","year":2017,"title":"Large-Scale Transposition Mutagenesis of Streptomyces coelicolor Identifies Hundreds of Genes Influencing Antibiotic Biosynthesis.","URL":null,"raw_pages":"e02889-16","medline_journal":"Appl Environ Microbiol","ISO_journal":"Appl Environ Microbiol","authors":["Xu Z","Wang Y","Chater KF","Ou HY","Xu HH","Deng Z","Tao M."],"DOI_URL":"https://doi.org/10.1128/AEM.02889-16"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":1,"interactions":0,"matches":884,"pathways":0,"proteins":884,"proteomes":832,"sets":0,"structural_models":{"alphafold":397},"structures":0,"taxa":889},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":10,"alignment:full":424},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}