This entry represents a family of uncharacterised proteins of approximately 145 residues found in Bacillota (particularly Paenibacillaceae and Bacillaceae) and Actinomycetota (including Streptomycetaceae). The proteins occur as single-domain proteins. While computationally annotated as phage tail proteins in UniProt, there is no experimental evidence supporting this function, and the annotation likely reflects genomic proximity to prophage regions rather than demonstrated function. The function of this family remains to be determined.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":null,"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":1,"interactions":0,"matches":969,"pathways":0,"proteins":969,"proteomes":907,"sets":0,"structural_models":{"alphafold":552},"structures":0,"taxa":1299},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":89,"alignment:full":480},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}