This family represents a small domain of approximately 93 amino acids found predominantly in Actinobacteria including Streptomyces, Thermomonosporaceae, and Streptosporangiaceae. The domain is also found in some cyanobacteria. The domain is typically found as the sole domain in uncharacterized proteins and shows genomic context association with DUF6745 domain proteins.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":null,"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":1,"interactions":0,"matches":1024,"pathways":0,"proteins":1024,"proteomes":893,"sets":0,"structural_models":{"alphafold":576},"structures":0,"taxa":1412},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":200,"alignment:full":497},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}