{"metadata":{"accession":"PF31126","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR061880","hierarchy":null,"name":{"name":"Domain of unknown function (DUF8819)","short":"DUF8819"},"description":[{"text":"<p>This family represents small uncharacterized proteins of approximately 108 residues found in Actinomycetes, particularly Streptomyces and Nocardioides. These proteins typically consist of this single domain only. STRING network analysis shows strong functional association with SIS domains ([pfam:PF01380]) and HTH_6 transcription factors ([pfam:PF01418]), suggesting a possible role in sugar metabolism regulation.</p>","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"<p>A <b>domain of unknown function</b> (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.</p>","thumbnail":null}],"literature":null,"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":1,"interactions":0,"matches":981,"pathways":0,"proteins":981,"proteomes":974,"sets":0,"structural_models":{"alphafold":451},"structures":0,"taxa":1059},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":59,"alignment:full":490},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}