This entry represents a domain of approximately 70 residues found in BPTF (Bromodomain PHD finger transcription factor) proteins and related DDT domain-containing proteins in eukaryotes. This domain is located downstream of the WSD domain ([pfam:PF15613]). BPTF is a subunit of the NURF chromatin remodelling complex that catalyses ATP-dependent nucleosome sliding [[cite:PUB00101089]]. In plant RLT (RINGLET) proteins, this domain is also present downstream of the WSD domain. The function of this domain remains to be determined.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00101089":{"PMID":28801535,"ISBN":null,"volume":"18","issue":"10","year":2017,"title":"Expansion of the ISWI chromatin remodeler family with new active complexes.","URL":null,"raw_pages":"1697-1706","medline_journal":"EMBO Rep","ISO_journal":"EMBO Rep","authors":["Oppikofer M","Bai T","Gan Y","Haley B","Liu P","Sandoval W","Ciferri C","Cochran AG."],"DOI_URL":null}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":200,"interactions":0,"matches":5604,"pathways":0,"proteins":5603,"proteomes":1563,"sets":0,"structural_models":{"alphafold":1103},"structures":0,"taxa":4976},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":87,"alignment:full":3855},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}