This entry represents a domain of approximately 70 residues found almost exclusively in spiders (Araneae), particularly in the families Araneidae and Nephilidae. The domain is found in one to three copies per protein. Some family members occur in proteins that also contain a GEMIN2/SIP1 domain ([pfam:PF04938]). The function of this domain remains to be determined.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":null,"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":112,"interactions":0,"matches":3124,"pathways":0,"proteins":3113,"proteomes":166,"sets":0,"structural_models":{"alphafold":2736},"structures":0,"taxa":813},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":87,"alignment:full":2418},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}