{"metadata":{"accession":"PF30886","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR061816","hierarchy":null,"name":{"name":"Domain of unknown function (DUF8755)","short":"DUF8755"},"description":[{"text":"<p>This entry represents a small N-terminal domain of approximately 40 residues found in bacterial signal transduction histidine kinases and diguanylate cyclases. The domain is composed of an alpha helix and beta hairpin. It is located N-terminal to PAS domains ([pfam:PF00989]) and ultimately HisKA ([pfam:PF00512]) and HATPase_c ([pfam:PF02518]) domains. This family is found in bacteria, predominantly Pseudomonadota and Bacteroidota. The function of this domain remains to be determined.</p>","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"<p>A <b>domain of unknown function</b> (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.</p>","thumbnail":null}],"literature":null,"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":136,"interactions":0,"matches":537,"pathways":0,"proteins":537,"proteomes":527,"sets":0,"structural_models":{"alphafold":357},"structures":0,"taxa":993},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":203,"alignment:full":276},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}