This entry represents a C-terminal transmembrane domain of approximately 160 residues found in a subset of glycosyltransferase family 2 (GT2) proteins. The domain is predicted to contain four transmembrane helices and is located C-terminal to the catalytic GT2 domain ([pfam:PF00535]). This domain architecture is characteristic of multi-component transmembrane glycosylation systems involved in cell wall polymer modification. This family is found in bacteria, predominantly Bacteroidota, Cyanobacteriota, and Bacillota. The function of this domain remains to be determined.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
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