This entry represents a C-terminal domain of approximately 65 residues found in ABC transporter ATP-binding proteins. The domain is located C-terminal to ABC_tran ([pfam:PF00005]) and AAA_21 ([pfam:PF13304]) domains. Many of these proteins are annotated as multidrug ABC transporters or ABC-2 type transport systems, including some daunorubicin/doxorubicin resistance proteins. This family is found almost exclusively in Actinomycetota, particularly Streptomyces. The function of this domain remains to be determined.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
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