This entry represents a domain of unknown function found in uncharacterised membrane proteins from plants. The domain is restricted to eudicots, specifically to the rosid clade, and is found in families including Rosaceae (roses, apples), Salicaceae (willows, poplars), and Malvaceae. The proteins containing this domain are predicted to be membrane associated. The function of this domain remains to be determined. This domain contains an helical fold.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":null,"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":41,"interactions":0,"matches":1876,"pathways":0,"proteins":1739,"proteomes":194,"sets":0,"structural_models":{"alphafold":1372},"structures":1,"taxa":505},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":14,"alignment:full":1099},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}