This entry represents a small N-terminal domain of approximately 60 residues found in bacterial proteins. This family is found predominantly in Actinomycetota, particularly in the orders Kitasatosporales, Micrococcales, and Streptomycetales. The family is also present in Chloroflexota. Structure prediction suggests that this domain will form a homodimeric structure. The function of this domain remains to be determined.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":null,"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":15,"interactions":0,"matches":1544,"pathways":0,"proteins":1544,"proteomes":1053,"sets":0,"structural_models":{"alphafold":890},"structures":0,"taxa":1526},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":281,"alignment:full":803},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}